Departments Pharmacodinamy
Head:
Hossein Hosseinzadeh (Pharm.D, PhD)
Manager:
Vahide sadat Moatamedolshariati (Pharm.D.)

Research Interests:

Toxicological and pharmacological investigations of chemical agents and herbal medicines with emphasis on native plants such as Crocus sativus L. (Saffron) and Salvia leriifolia (Nourozak)

Investigations:

  • Antinociceptic effects of crocin and safranal in mice.

  • Protective effect of aqueous and ethanolic extracts of Salvia leriifolia on diminishing damages caused by renal ischemia in rats.

  • Protective effect of saffron aqueous extract and crocin, as one of the active constituent of saffron on diminishing damages caused by renal ischemia in rats.

  • Acute and subacute toxicity effects of crocin and safranal in rats

  • Antidepressant effect of N-substituted imidazole carboxamides in the forced swimming test model in mice.

  • Effects of aqueous extract of Pinus eldarica (pine fruit) in treatment or prevention of renal calcium oxalate formation.

  • Effects of Crocus sativus aqueous extract and its two constituents, crocin and safranal, in an experimental Multiple Sclerosis model in rats.

  • Protective effect of the saffron stigma in reduction of reperfusion syndrome lesions after vascular clamping of the lower limb

  • Effect of saffron aqueous extract and its two constituents, crocin and safranal, on the prevention of cataract caused by galactose in rats

Select Publication:

  • Razavi BM, Hosseinzadeh H (2015). Saffron as an antidote or a protective agent against natural or chemical toxicities. Daru 23: 31.

  • Rashedinia M, Lari P, Abnous K, Hosseinzadeh H (2015). Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain. Acta Neurobiol Exp (Wars) 75: 208-219.

  • Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H (2012). Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 32: 227-235.

 
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