The major focus of the laboratory is on the development of novel gene delivery systems to achieve an appropriate vector for gene therapy.
- Developing polymer-based (especially PEI-based) gene delivery systems.
- The objective of these studies is to achieve novel non-viral vectors with an improved ability of getting gene inside cells.
- Developing peptide-based non-viral gene delivery systems.
- The emphasis of these studies is to design vectors, which cannot serve many functions that other types of non-viral vectors can not perform alone.
- Liposome-based delivery of gene using different approaches
- Preparation and evaluation of nano-sized lipoplexies as a non-viral in gene therapy: effect of bilayer fluidity of cationic liposome’s on transfection efficiency.
- Preparation and evaluation of glactosylated lipoplexes as non-viral vector: effect of cholesterol derivatives on transfection efficiency.
Application of recombinant fusion proteins for gene delivery.
Because of having precise composition, sequence and length, these types of vectors can be good options for cancer gene therapy.