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Dr: Soghra Mehri
Assistant Professor of Pharmacodynamics and Toxicology
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Address: Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad-Iran
Tel: ++98-51-38823255 Fax: ++98-51-38823251
This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it. Updated at: 7/2/2016 |
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und Educational Background |
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Pharm D: School of pharmacy, Mashhad University of Medical Sciences, Iran (1998-2004)
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Ph.D of Toxicology: Department of Pharmacodynamics and Toxicology, Mashhad University of Medical Sciences, Iran (2007-2012)
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Sabbatical course: Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany (2011 January- 2011 July)
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Research Interests |
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Neurotoxicity (Different mechanisms of induction and protection) |
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Primary cell culture preparation as a suitable in vitro model foe evaluation neurotoxicity and neuroprotection |
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Cellular and molecular signaling pathways |
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Evaluation of biologic effects of herbal medicine |
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Publications |
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1) Karimi, Gh., Hassanzadeh, M. and Mehri, S. Protective Effect of Rosmarinus officinalis L. |
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2) Karimi, Gh., Hassanzadeh, M. and Mehri, S. Protective Effects of Silymarin against Free Radical-Induced Erythrocyte Lysis. Journal of Complementary and Integrative Medicine, 2006, 3. |
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3) Hosseinzadeh, H., Shamsaie, F. and Mehri, S. Antioxidant Activity of Aqueous and Ethanolic Extracts of Crocus sativus L. Stigma and its Bioactive Constituents, Crocin and Safranl. Pharmacognosy Magazine, 2009, 20, 419-424. |
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4) Mousavi, S.H., Moallem S.A., Mehri, S. Shahsavand, Sh., Nasirli, H. and Malaekeh, B. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Pharmaceutical biology, 2011, 49: 1035-1045. 5) Rasekh, H.R., Hosseinzadeh, L., Mehri, S. Kamli-Nejad, M., Aslani, M., Tanbakoosazan, F., and Almousavi, M. Safety assessment of Ocimum basilicum hydroalcholic extract in wistar rats: Acute and subchronic toxicity studies. Iranian Journal of Basic Medical Sciences, 2012, 15: 645-653. |
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6) Hosseinzadeh, H., Sajadi Tabasi, A., Milani Moghadam, N., Rashedinia, R. and Mehri, S. Antioxidant activity of Pistacia vera fruits, leaves and gum extracts Iranian Journal of Pharmaceutical Research, 2012, 11: 879-887. |
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7) Mehri, S. Abnous, Kh., Mousavi, S.H. Motamed shariaty, V. Hosseinzadeh, H. Neuroprotective effect of crocin on acrylamide-induced cytotoxiciyt in PC 12 cells. Cellular and Molecular Neurobiology, 2012, 32: 227-235. |
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8) Mehdizadeh, R., Khooei, A., Parizadeh, M., Mehri, S. Hosseinzadeh, H Cardioprotective Effect of Saffron Extract and Safranal in Isoproterenol-Induced Myocardial Infarction in wistar Rats. Iranian Journal of Basic Medical Sciences , 2013, 16, 56-63. |
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9) Badiyan, Z. Moallem S.A, Mehri, S., Shahsavand, Sh, Hadizadeh, F. Virtual screening for novel COX-2 inhibitors as antitumor agents using the ZINC database. The open Medicinal Chemistry Journal, 2012, 6: 15-19. |
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10) Hosseinzadeh, H., Mehri, S. Abolhassani, MM., Ramezani, M., Sahebkar, A., Abnous, K. Affinity-based target deconvolution of safranal. DARU Journal of Pharmaceutical Sciences, 2013, 20; 21(1):25. |
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11) Malaekeh, B. Mousavi, S.H, Shahsavand, Sh, Mehri, S., Nasirli, H and Moallem S.A. Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines, Phytotherapy Research , 2013 (Dec) 27(12):1868-73. |
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12) Hosseinzadeh, H., Mehri, S., Heshmati, A., Ramezani, M., Sahebkar, A., and Abnous, Kh. Proteomic screening of molecular targets of crocin. DARU Journal of Pharmaceutical Sciences 2014, 6; 22(1):5. |
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13) Abnous, K., Barati, B., Mehri, S., Masboghi Farimani, MR., Alibolandi, M., Mohammadpour, F., Ghandadi, M., Hadizadeh, F. Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line. DARU Journal of Pharmaceutical Sciences , 2013, 19;21(1):70 |
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14) Vahdati Hassani, F Naseri, V., Razavi, BM., Mehri, S., Abnous, K., Hosseinzadeh, H. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. DARU Journal of Pharmaceutical Sciences, 2014, 8; 22(1):16. |
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15) Mehri, S., Karami, HV. Hassani, FV. Hosseinzadeh, H. Chrysin Reduced Acrylamide-Induced Neurotoxicity in both in vitro and in vivo Assessments. Iranian Biomedical Journal 2014; 18(2):101-6. |
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16) Jamialahmadi, K, Arasteh, O, Matbou Riahi, M.b, Mehri, S, Riahi-Zanjani, B, Karimi, G. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environmental Toxicology and Pharmacology, 2014, 38 (1): 212-219. |
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17) Ghorbani, M, Mohamadpour, AH, Mehri, S, Abnous, Kh, Hassanzadeh-Khayyat, M. Proteomics screening of molecular targets of granulocyte colony stimulating factor in the mouse brain and PC12 cell line. Life Science, 2014, 108(1):44-47. |
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18) Rubini, P, Pagel, G, Mehri, S, Marquardt, P, Riedel, T, Illes, P. Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons. Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, 387(10):943-954 |
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19) Davari, A.S, Abnous, K. Mehri, S, Ghandadi, M, Hadizadeh,F. Synthesis and biological evaluation of novel pyridine derivatives as potential anticancer agents and phosphodiesterase-3 inhibitors. Bioorganic Chemistry, 2014, 57:83-89. |
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20) Mehri, S, Shahi, M, Razavi, BM, Vahdati Hassani, F, Hosseinzadeh, H. |
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21) Ghasemi, T., Abnous, Kh., Vahdati Hassani, F., Mehri, S,. Razavi, BM. Hoseinzadeh, H, Antidepressant effect of Crocus sativus aqueous extract and its effect on CREB, BDNF, and VGF transcript and protein levels in rat hippocampus. Drug Research, 2015, 65 (7): 337-343. |
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22) Mehri S, Meshki MA, Hosseinzadeh H. Linalool as a neuroprotective agent against acrylamide-induced neurotoxicity in Wistar rats. Drug Chemical Toxicology, 2015, 38(2): 162-166. |
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23) Moallem, SA, Dehghani, N, Mehri, S, Alibolandi, M, Hadizadeh, F.Synthesis of novel 1,8-acridinediones derivatives: Investigation of MDR reversibility on breast cancer cell lines T47D and tamoxifenresistant T47D. Research in Pharmaceutical Sciences, 2015, 10 (3): 214-221. |
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24) Mehri, S, Abnous, K, Khooei, A, Shariaty, V.M, Hosseinzadeh, H. Crocin reduced acrylamide-induced neurotoxicity in wistar rat through inhibition of oxidative stress. Iranian Journal of Basic Medical Sciences, 2015, 18 (9): 902-908. |
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25) Akaberi, M, Mehri, S, Iranshahi, M. Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species. Fitoterapia , 2016, 30 (6): 878-893. |
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26) Ghanbarabadi, M, Iranshahi, M, Amoueian, S, Mehri, S, Motamedshariaty, V.S, Mohajeri, S.A. Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation. Neuroscience Letters, 2016, 623(3): 13-21. |
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Presentations |
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1) Hosseinzadeh, H., Shamsaie, F. and Mehri, S. Antioxidant Activity of Aqueous and Ethanolic Extracts of Crocus sativus L. Stigma and its Bioactive Constituents, Crocin and Safranl. International Symposium on Saffron a Herbal Medicine of 3rd Millennium, May 13 -14, 2009, Mashhad, Iran. Poster |
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2) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Acrylamide and Neurotoxicity. First Iranian Congress on Acrylamide and Its Challengess on Food Industry. May 27, 2010, Mashhad, Iran. Poster. |
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3) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Protective effect of crocin on acrylamide – induced cytotoxicity in PC 12 cells. 12 th Iranian Pharmaceutical Sciences Congress (IPSC 2010), August 2– 5, 2010, Zanjan, Iran. Poster |
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4) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Neurotoxicity of Acrylamide in occupational exposure. Iranian Congress of Addiction, Poisoning and nursing Care. October 27-29, 2010, Mashhad, Iran. Poster 5) Mehri, S. Shahsavand, Sh. Moallem, SA. Malaekeh, B. Moosavi, S.H. Nassirli,H. Safranal and Its Nanoliposoms- Induced Cytotoxicity in Hela and MCF7 cancer cell lines. The First International Student Congress on Cell and Molecular Medicine. February 17-19, 2011, Shiraz, Iran. Poster |
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6) Mehri, S. Hosseinzadeh, H. Mehdizadeh, R. Khooei, A. Parizadeh, M. Preventive effect if Crocus sativus L. stigma extract on biochemical, antioxidant and histopathological alterations in isoproterenol – induced cardiotoxicity in wistar rats. 12th Iranian Congress of Biochemistry & 4 th International Congress of Biochemistry & Molecular Biology, September 6-9, 2011. Mashhad, Iran. Oral |
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7) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Protective effect of crocin on Acrylamide- induced neurotoxicity in wistar rats. 20 th Iranian Congress of Physiology and pharmacology, 2011, Hamedan, Iran. Poster |
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8) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Apoptotic protein- expression profiles in rat cerebral cortex following exposure to acrylamide. 11 th International Iranian Toxicology Congress. September 13-15, 2011, Mashhad, Iran. Poster |
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9) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H. Crocin decreased acrylamide – induced neurotoxicity in wistar rat through oxidative stress and apoptosis pathway. 13 th Iranian Pharmaceutical Sciences Congress (IPSC 2012), Isfahan-Iran. Oral |
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10) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H, Khoei. Vitamin E as an antiapoptotic and antioxidant agent in Acrylamide-induced neurotoxicity in wistar rats. 12 th Iranian Toxicology Congress. May 15-17, 2013, Sari- Iran. Poster |
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11) Mehri, S., Illes, P., Reidel, T. P2X7 receptors at neurons and astrocytes of cultured hippocampal and cortical cells of the rat. 21st International Iranian Congress of Physiology and Pharmacology- 23-27 August, 2013, Tabriz-Iran. Oral Presentation. |
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12) Mehri, S. Meshki, MA., Hosseinzadeh, H. Evaluation of linalool effect on acrylamide induced neurotoxicity in wistar rat. 21st International Iranian Congress of Physiology and Pharmacology- 23-27 August, 2013, Tabriz-Iran. Poster Presentation. |
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13) Mehri, S. Hosseinzadeh, H., Abnous, Kh., Mousavi, S.H, Khoei. Reduction of acrylamide-induced neurotoxicity in cerebellum tissue following administration of crocin. |
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14) Mehri, S. Khezri, A., Hosseinzadeh, H. Effect of quetiapine on attenuation of morphine-induced conditioned place preference: Evaluation of CREB, p-CREB, ERK and p-ERK proteins level in rat hippocampus. 13th Iranian International Congress of Toxicology. May 12-14, 2015, URMIA. Poster Presentation. |
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15) Mehri, S. Sajjadi, SS., Hosseinzadeh, H. Effects of clavulanic acid on the acquisition and reinstatement of morphineinduced conditioned place preference in mice. 1st International and 22 nd Iranian Congress of Physiology and Pharmacology. September 7-11, 2015, Kashan. Poster Presentation. |
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16) Mehri, S. Dadesh, Q., Hosseinzadeh, H. Neuroprotective effect of silymarin against acrylamide-induced neurotoxicity in both in vitro and in vivo assessments. The First International Cingress of Complementary and Alternative Medicine. October 7-9, 2015, Mashhad. Poster Presentation. |
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17) Mehri, S. Foroutan far, A., Hosseinzadeh, H. Hepatoprotective effect of punicalagin against acrylamide-induced toxicity in Wistar rat. 14th Iranian Pharmaceutical Sciences Congress, 1st Symposium of Biopharmaceutics and Pharmacokinetics. December 21-24, 2015, Tehran. Poster Presentation. |
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Honors & Awards |
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2011: The winner of the best oral presentation, PhD student’s research festival, Mashhad University of Medical Sciences, Mashhad. |
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2015: The second rank, Poster presentation, 14th Iranian Pharmaceutical Sciences Congress, 1st Symposium of Biopharmaceutics and Pharmacokinetics, Tehran |
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Members hip Membership |
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Iranian Association of Pharmaceutical Scientists |
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Iranian Society of Physiology and Pharmacology |
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Administrative Responsibilities |
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Other Skills |
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