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Khalil Abnous (Pharm.D, Ph.D)
Associate Professor Medicinal Chemistry |
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Address: Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad, Iran Tel.: +98 513 882 3268 Fax: +98 513 882 3268 Email: This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it. Updated at: |
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und Educational Background |
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School of Pharmacy, Mashad University of Medical Sciences, Iran Pharm D supervisor: Dr Saberi, Dr Rahimizadeh Research Field: Organic Chemistry Pharm D thesis: Synthesis of 17, 21 dihydroxy progesterone
Department of Chemistry, Carleton University, Canada PhD supervisor: Prof. K.B. Storey Research Field: Enzyme Biochemistry and Biotechnology PhD thesis: Regulation of Metabolic Enzymes in Hibernation Department of Chemistry, Carleton University, Canada PDF Supervisor : Dr Maria DeRosa Research Field: SELEX; Aptamer Department of Nutrition Research, Health Canada, Ottawa, Canada PDF Supervisor : Dr Steve Brooks Research Field: Microbiology, Proteomics (hydrolytic Enzymes) and Genomics (16S rRNA) Department of Chemistry, Carleton University, Canada Sabbatical Supervisor : Dr Maria DeRosa Research Field: Aptasensors |
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Research Interests |
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Development of Aptamers for new targets Fabrication of New aptasensors Proteomics |
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Publications |
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1. Taghdisi, S.M., Danesh, N.M., Lavaee, P., Ramezani, M., Abnous, K*. An electrochemical aptasensor based on gold nanoparticles, thionine and hairpin structure of complementary strand of aptamer for ultrasensitive detection of lead (2016) Sensors and Actuators, B: Chemical, 234, pp. 462-469. (IF=4.758) 2. Razavi BM, Hosseinzadeh H, Abnous K, Khoei A, Imenshahidi M. Protective effect of crocin against apoptosis induced by subchronic exposure of the rat vascular system to diazinon. Toxicol Ind Health. 2016 Jul;32(7):1237-45. (IF= 1.688)
3. Nameghi MA, Danesh NM, Ramezani M, Hassani FV, Abnous K*, Taghdisi SM. A fluorescent aptasensor based on a DNA pyramid nanostructure for ultrasensitive detection of ochratoxin A. Anal Bioanal Chem. 2016 Jun 16. [Epub ahead of print] (IF=3.125)
4. Aghebati T, Badiee A, Mohammadpour AH, Afshar M, Jaafari MR, Abnous K, Issazadeh S, Hashemzadeh S, Zareh M, Hashemizadeh H, Nazemi S. Anti-atherosclerosis effect of different doses of CETP vaccine in rabbit model of atherosclerosis. Biomed Pharmacother. 2016 Jul;81:468-73. (IF= 2.326)
5. Moghadam M, Sankian M, Abnous K, Varasteh A, Taghdisi SM, Mahmoudi M, Ramezani M, Gholizadeh Z, Ganji A. Cell-SELEX-based selection and characterization of a G-quadruplex DNA aptamer against mouse dendritic cells. Int Immunopharmacol. 2016 Jul;36:324-32. (IF= 2.551)
6. Taghdisi SM, Danesh NM, Ramezani M, Abnous K*. A novel M-shape electrochemical aptasensor for ultrasensitive detection of tetracyclines. Biosens Bioelectron. 2016 May 15;85:509-514. doi: 10.1016/j.bios.2016.05.048. [Epub ahead of print] (IF=7.476)
7. Yazdian-Robati R, Ramezani M, Jalalian SH, Abnous K*, Taghdisi SM. Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo. Pharm Res. 2016 Jun 9. [Epub ahead of print] (IF=3.26)
8. Soheili, V., Taghdisi, S.M., Hassanzadeh Khayyat, M., Fazly Bazzaz, B.S., Ramezani, M., Abnous, K*. Colorimetric and ratiometric aggregation assay for streptomycin using gold nanoparticles and a new and highly specific aptamer(2016) Microchimica Acta, pp. 1-11. Article in Press. (IF= 4.831)
9. Askarian S, Abnous K, Darroudi M, Oskuee RK, Ramezani M. Gene delivery to neuroblastoma cells by poly (l-lysine)-grafted low molecular weight polyethylenimine copolymers. Biologicals. 2016 Apr 23. pii: S1045-1056(16)30002-1. doi: 10.1016/j.biologicals.2016.03.007. [Epub ahead of print] PubMed PMID: 27118207. (IF= 1.69 )
10. Robati RY, Arab A, Ramezani M, Langroodi FA, Abnous K*, Taghdisi SM. Aptasensors for quantitative detection of kanamycin. Biosens Bioelectron. 2016 Apr 5;82:162-172. doi: 10.1016/j.bios.2016.04.011. [Epub ahead of print] Review. PubMed PMID: 27085947. (IF=7.476)
11. Teimouri M, Nia AH, Abnous K*, Eshghi H, Ramezani M. Graphene oxide-cationic polymer conjugates: Synthesis and application as gene delivery vectors. Plasmid. 2016 Apr 9;84-85:51-60. doi: 10.1016/j.plasmid.2016.03.002. [Epub ahead of print]PubMed PMID: 27072918. (IF= 1.732 )
12. Abnous K, Danesh NM, Sarreshtehdar Emrani A, Ramezani M, Taghdisi SM. A novel fluorescent aptasensor based on silica nanoparticles, PicoGreen and exonuclease III as a signal amplification method for ultrasensitive detection of myoglobin. Anal Chim Acta. 2016 Apr 21;917:71-8. doi: 10.1016/j.aca.2016.02.036. Epub 2016 Mar 5. PubMed PMID: 27026602. (IF= 4.712 )
13. Razavi-Azarkhiavi K, Jafarian AH, Abnous K, Razavi BM, Shirani K, Zeinali M, Jaafari MR, Karimi G. The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study. Drug Res (Stuttg). 2016 Mar 29. [Epub ahead of print] PubMed PMID: 27022719. (IF= 0.71 )
14. Taghdisi SM, Danesh NM, Ramezani M, Lavaee P, Jalalian SH, Robati RY, Abnous K*. Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo. Eur J Pharm Biopharm. 2016 May;102:152-8. doi: 10.1016/j.ejpb.2016.03.013. Epub 2016 Mar 14. PubMed PMID: 26987703. (IF= 3.975)
15. Taghdisi SM, Danesh NM, Nameghi MA, Ramezani M, Abnous K*. A label-free fluorescent aptasensor for selective and sensitive detection of streptomycin in milk and blood serum. Food Chem. 2016 Jul 15;203:145-9. doi: 10.1016/j.foodchem.2016.02.017. Epub 2016 Feb 2. PubMed PMID: 26948599. (IF= 4.052 )
16. Alibolandi M, Alabdollah F, Sadeghi F, Mohammadi M, Abnous K, Ramezani M, Hadizadeh F. Dextran-b-poly(lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation. J Control Release. 2016 Apr 10;227:58-70. doi: 10.1016/j.jconrel.2016.02.031. Epub 2016 Feb 21. PubMed PMID: 26907831. (IF= 7.441 )
17. Nia AH, Amini A, Taghavi S, Eshghi H, Abnous K, Ramezani M. A facile Friedel-Crafts acylation for the synthesis of polyethylenimine-grafted multi-walled carbon nanotubes as efficient gene delivery vectors. Int J Pharm. 2016 Apr 11;502(1-2):125-37. doi: 10.1016/j.ijpharm.2016.02.034. Epub 2016 Feb22. PubMed PMID: 26906459. (IF= 3.994)
18. Taghdisi SM, Danesh NM, Ramezani M, Emrani AS, Abnous K*. A novel electrochemical aptasensor based on Y-shape structure of dual-aptamer-complementary strand conjugate for ultrasensitive detection of myoglobin. Biosens Bioelectron. 2016 Jun 15;80:532-7. doi: 10.1016/j.bios.2016.02.029. Epub 2016 Feb 11. PubMed PMID: 26894983. (IF=7.476)
19. Ghandadi M, Behravan J, Abnous K, Mosaffa F. Reactive Oxygen Species Mediate TNF-x237A; Cytotoxic Effects in the Multidrug-Resistant Breast Cancer Cell Line MCF-7/MX. Oncol Res Treat. 2016;39(1-2):54-9. doi: 10.1159/000442144. Epub 2015 Dec 21. PubMed PMID: 26890889.
20. Alibolandi M, Ramezani M, Abnous K*, Hadizadeh F. AS1411 Aptamer-Decorated Biodegradable Polyethylene Glycol-Poly(lactic-co-glycolic acid) Nanopolymersomes for the Targeted Delivery of Gemcitabine to Non-Small Cell Lung Cancer In Vitro. J Pharm Sci. 2016 May;105(5):1741-50. doi: 10.1016/j.xphs.2016.02.021. Epub 2016 Mar 30. PubMed PMID: 27039356. (IF: 2.641)
21. Abnous, K., Danesh, N.M., Ramezani, M., Taghdisi, S.M., Emrani, A.S. A novel electrochemical aptasensor based on H-shape structure of aptamer-complimentary strands conjugate for ultrasensitive detection of cocaine (2016) Sensors and Actuators, B: Chemical, (2016) 224, pp. 351-355. (IF=4.758)
22. Ramezani, M., Danesh, N.M., Lavaee, P., Abnous, K*., Taghdisi, S.M. A selective and sensitive fluorescent aptasensor for detection of kanamycin based on catalytic recycling activity of exonuclease III and gold nanoparticles(2016) Sensors and Actuators, B: Chemical, 222, pp. 1-7. (IF=4.758).
23. Yazdian-Robati, R., Pourtaji, A., Rashedinia, M., Hosseinzadeh, H., Ghorbani, M., Razavi, B.M., Ramezani, M., Abnous, K*. Screening and identification of SUMO-proteins in sub-acute treatment with diazinon (2015) Iranian Journal of Basic Medical Sciences, 18 (12), pp. 1240-1244. (IF= 1.220 )
24. Hashemi M, Tabatabai SM, Parhiz H, Milanizadeh S, Amel Farzad S, Abnous K*, Ramezani M. Gene delivery efficiency and cytotoxicity of heterocyclic amine-modified PAMAM and PPI dendrimers. Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:791-800. (IF= 3.420 )
25. Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, Abnous K*. Double targeting, controlled release and reversible delivery of daunorubicin to cancer cells by polyvalent aptamers-modified gold nanoparticles. Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:753-61(IF= 3.420 )
26. Hashemzaei M, Imen Shahidi M, Moallem SA, Abnous K, Ghorbani M, Mohamadpour AH. Modulation of JAK2, STAT3 and Akt1 proteins by granulocyte colony stimulating factor following carbon monoxide poisoning in male rat. Drug Chem Toxicol. 2016 Jan 25:1-5. (IF= 1.653 )
27. Alibolandi M, Abnous K, Sadeghi F, Hosseinkhani H, Ramezani M, Hadizadeh F. Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation. Int J Pharm. 2016 Jan 21;500(1-2):162-178. (IF= 3.994)
28. Taghdisi SM, Danesh NM, Beheshti HR, Ramezani M, Abnous K*. A novel fluorescent aptasensor based on gold and silica nanoparticles for the ultrasensitive detection of ochratoxin A. Nanoscale. 2016 Feb 14;8(6):3439-46. (IF= 7.760 )
29. Taghavi S, HashemNia A, Mosaffa F, Askarian S, Abnous K*, Ramezani M. Preparation and evaluation of polyethylenimine-functionalized carbon nanotubes tagged with 5TR1 aptamer for targeted delivery of Bcl-xL shRNA into breast cancer cells. Colloids Surf B Biointerfaces. 2015 Dec 17;140:28-39. (IF= 3.902 )
30. Dorri SA, Hosseinzadeh H, Abnous K, Hasani FV, Robati RY, Razavi BM. Involvement of brain-derived neurotrophic factor (BDNF) on malathion induced depressive-like behavior in subacute exposure and protective effects of crocin. Iran J Basic Med Sci. 2015 Oct;18(10):958-66. . (IF= 1.22 )
31. Moosavian SA, Abnous K*, Badiee A, Jaafari MR. Improvement in the drug delivery and anti-tumor efficacy of PEGylated liposomal doxorubicin by targeting RNA aptamers in mice bearing breast tumor model. Colloids Surf B Biointerfaces. 2016 Mar 1;139:228-36. (IF= 3.902 )
32. Pourtaji A, Robati RY, Lari P, Hosseinzadeh H, Ramezani M, Abnous K*. Proteomics screening of adenosine triphosphate-interacting proteins in the liver of diazinon-treated rats. Hum Exp Toxicol. 2015 (IF= 1.604 )
33. YahyaHanafi-Bojd M, Jaafari MR, Ramezanian N, Abnous K, Malaekeh-Nikouei B. Co-delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy. Curr Drug Deliv. 2015 (IF: 1.446)
34. Emrani AS, Danesh NM, Ramezani M, Taghdisi SM, Abnous K*. A novel fluorescent aptasensor based on hairpin structure of complementary strand of aptamer and nanoparticles as a signal amplification approach for ultrasensitive detection of cocaine. Biosens Bioelectron. 2016 May 15;79:288-93. (IF=7.476)
35. Mokhtarzadeh A, Parhiz H, Hashemi M, Abnous K*, Ramezani M. P53-Derived peptides conjugation to PEI: an approach to producing versatile and highly efficient targeted gene delivery carriers into cancer cells. Expert Opin Drug Deliv. 2016 Jan 8:1-15. (IF= 5.434 )
36. Khedri M, Rafatpanah H, Abnous K, Ramezani P, Ramezani M. Cancer immunotherapy via nucleic acid aptamers. Int Immunopharmacol. 2015 Dec;29(2):926-36. (IF= 2.551)
37. Abnous K, Danesh NM, Ramezani M, Emrani AS, Taghdisi SM. A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol. Biosens Bioelectron. 2016 (IF=7.476)
38. Lavaee P, Eshtiagh-Hosseini H, Housaindokht MR, Mague JT, Esmaeili AA, AbnousK. Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex. J Fluoresc. 2016 Jan;26(1):333-44. (IF= 1.601 )
39. Mehri S, Abnous K, Khooei A, Mousavi SH, Shariaty VM, Hosseinzadeh H. Crocin reduced acrylamide-induced neurotoxicity in Wistar rat through inhibition of oxidative stress. Iran J Basic Med Sci. 2015 Sep;18(9):902-8. (IF= 1.22 )
40. Ghorbani M, Mohammadpour AH, Abnous K, Movassaghi AR, Sarshoori JR,Shahsavand S, Hashemzaei M, Moallem SA. G-CSF administration attenuates braininjury in rats following carbon monoxide poisoning via different mechanisms. Environ Toxicol. 2015 Oct 27. (IF= 2.868 )
41. Askarian S, Abnous K, Taghavi S, Oskuee RK, Ramezani M. Cellular delivery of shRNA using aptamer-conjugated PLL-alkyl-PEI nanoparticles. Colloids Surf B Biointerfaces. 2015 Dec 1;136:355-64. (IF= 3.902 )
42. Moallem SA, Mohamadpour AH, Abnous K, Sankian M, Sadeghnia HR, Tsatsakis A, Shahsavand S. Erythropoietin in the treatment of carbon monoxide neurotoxicity in rat. Food Chem Toxicol. 2015 Dec;86:56-64. (IF= 3.584 )
43. Ghandadi M, Haj-Ali N, Behravan J, Abnous K, Mohammadi A, Gharaee ME, Mosaffa F. TNF-α exerts higher cytotoxic effect on MCF-7 multidrug resistant derivative, role of Akt activation. Breast Dis. 2015 Nov 17;35(4):241-7.
44. Mohammad Danesh N, Ramezani M, Sarreshtehdar Emrani A, Abnous K*, Taghdisi SM.A novel electrochemical aptasensor based on arch-shape structure of aptamer-complimentary strand conjugate and exonuclease I for sensitive detection of streptomycin. Biosens Bioelectron. 2016 Jan 15;75:123-8. (IF=7.476)
45. Ayatollahi S, Hashemi M, Kazemi Oskuee R, Salmasi Z, Mokhtarzadeh A, Alibolandi M, Abnous K*, Ramezani M. Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells.J Biomater Appl. 2015 Nov;30(5):632-48. (IF= 2.988 )
46. Rashedinia M, Lari P, Abnous K, Hosseinzadeh H. Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain. Acta Neurobiol Exp (Wars). 2015;75(2):208-19(IF= 2.707 ).
47. Moosavian SA, Jaafari MR, Taghdisi SM, Mosaffa F, Badiee A, Abnous K*. Development of RNA aptamers as molecular probes for HER2(+) breast cancer study using cell-SELEX. Iran J Basic Med Sci. 2015 Jun;18(6):576-86. . (IF= 1.22 )
48. Emrani AS, Danesh NM, Lavaee P, Ramezani M, Abnous K*, Taghdisi SM. Colorimetric and fluorescence quenching aptasensors for detection of streptomycin in blood serum and milk based on double-stranded DNA and gold nanoparticles. Food Chem. 2016 (IF= 4.052 )
49. Salmasi Z, Shier WT, Hashemi M, Mahdipour E, Parhiz H, Abnous K*, Ramezani M. Heterocyclic amine-modified polyethylenimine as gene carriers for transfection of mammalian cells. Eur J Pharm Biopharm. 2015 Oct;96:76-88 (IF= 3.975)
50. Alibolandi M, Sadeghi F, Abnous K, Atyabi F, Ramezani M, Hadizadeh F. The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model. Eur J Pharm Biopharm. 2015 Aug;94:521-31 (IF= 3.975)
51. Khansarizadeh M, Mokhtarzadeh A, Rashedinia M, Taghdisi SM, Lari P, Abnous KH, Ramezani M. Identification of possible cytotoxicity mechanism of polyethylenimine by proteomics analysis. Hum Exp Toxicol. 2015 (IF= 1.604 )
52. Khameneh B, Jaafari MR, Hassanzadeh-Khayyat M, Varasteh A, Chamani J, Iranshahi M, Mohammadpanah H, Abnous K, Saberi MR. Preparation, characterization and molecular modeling of PEGylated human growth hormone with agonist activity. Int J Biol Macromol. 2015 Sep;80:400-9. (IF= 3.138 )
53. Taghdisi SM, Danesh NM, Emrani AS, Ramezani M, Abnous K*. A novel electrochemical aptasensor based on single-walled carbon nanotubes, gold electrode and complimentary strand of aptamer for ultrasensitive detection of cocaine. Biosens Bioelectron. 2015 Nov 15;73:245-50. (IF=7.476)
54. Abrishami M, Hashemi B, Abrishami M, Abnous K, Razavi-Azarkhiavi K, Behravan J. PCR detection and identification of bacterial contaminants in ocular samples from post-operative endophthalmitis. J Clin Diagn Res. 2015 (IF= 0.23 )
55. Nourbakhsh M, Jaafari MR, Lage H, Abnous K, Mosaffa F, Badiee A, Behravan J. Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer. Iran J Basic Med Sci. 2015 Apr;18(4):385-92. . (IF= 1.22 )
56. Taghdisi SM, Danesh NM, Lavaee P, Ramezani M, Abnous K*. An aptasensor for selective, sensitive and fast detection of lead(II) based on polyethyleneimine and gold nanoparticles. Environ Toxicol Pharmacol. 2015 May;39(3):1206-11. (IF=2.187)
57. Danesh NM, Lavaee P, Ramezani M, Abnous K*, Taghdisi SM. Targeted and controlled release delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer-modified gold nanoparticles. Int J Pharm. 2015 Jul 15;489(1-2):311-7. (IF= 3.994)
58. Alibolandi M, Ramezani M, Abnous K, Sadeghi F, Atyabi F, Asouri M, Ahmadi AA,Hadizadeh F. In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer. J Control Release. 2015 Jul 10;209:88-100. (IF= 7.441 )
59. Emrani, A.S., Taghdisi, S.M., Danesh, N.M., Jalalian, S.H., Ramezani, M., Abnous, K*. A novel fluorescent aptasensor for selective and sensitive detection of digoxin based on silica nanoparticles(2015) Analytical Methods, 7 (9), pp. 3814-3818. (IF= 1.915 )
60. Sarreshtehdar Emrani, A., Danesh, N.M., Lavaee, P., Jalalian, S.H., Ramezani, M., Abnous, K*., Taghdisi, S.M. Sensitive and selective detection of digoxin based on fluorescence quenching and colorimetric aptasensors (2015) Analytical Methods, 7 (8), pp. 3419-3424(IF= 1.915 )
61. Khabbaz, L.S., Hassanzadeh-Khayyat, M., Zaree, P., Ramezani, M., Abnous, K*., Taghdisi, S.M. Detection of kanamycin by using an aptamer-based biosensor using silica nanoparticles (2015) Analytical Methods, 7 (20), pp. 8611-8616. (IF= 1.915 )
62. Jalalian, S.H., Taghdisi, S.M., Danesh, N.M., Bakhtiari, H., Lavaee, P., Ramezani, M., Abnous, K*. Sensitive and fast detection of tetracycline using an aptasensor(2015) Analytical Methods, 7 (6), pp. 2523-2528. (IF= 1.915 )
63. Alibolandi, M., Ramezani, M., Abnous, K., Sadeghi, F., Hadizadeh, F.Comparative evaluation of polymersome versus micelle structures as vehicles for the controlled release of drugs (2015) Journal of Nanoparticle Research, 17 (2), 16 p. (IF= 2.101 )
64. Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini SM, Hosseinzadeh H.Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci. 2014 Dec;17(12):1020-31. . (IF= 1.22 )
65. Ramezani M, Mohammad Danesh N, Lavaee P, Abnous K*, Mohammad Taghdisi S. A novel colorimetric triple-helix molecular switch aptasensor for ultrasensitive detection of tetracycline. Biosens Bioelectron. 2015 Aug 15;70:181-7. (IF=7.476)
66. Mohammadi M, Salmasi Z, Hashemi M, Mosaffa F, Abnous K*, Ramezani M. Single-walled carbon nanotubes functionalized with aptamer and piperazine-polyethylenimine derivative for targeted siRNA delivery into breast cancer cells. Int J Pharm. 2015 May 15;485(1-2):50-60. (IF= 3.995 )
67. Mokhtarzadeh A, Parhiz H, Hashemi M, Ayatollahi S, Abnous K*, Ramezani M. Targeted Gene Delivery to MCF-7 Cells Using Peptide-Conjugated Polyethylenimine. AAPS PharmSciTech. 2015 (IF= 1.954)
68. Rahimi HR; Jaafari MR; Mohammadpour AH;Abnous K;Ghayour Mobarhan M;Ramezanzadeh E; Mousavi F;Kazemi Oskuee R. Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease, Asia Pacific Journal of Medical Toxicology, 2015, 4(1): 25-3
69. Rezaee R, Jamialahmadi K, Riahi Zanjani B, Mahmoudi M, Abnous K, Zamani Taghizadeh Rabe S, Tabasi N, Zali M, Rezaee M, Amin B, Karimi G. Crocin effects on human myeloma cells regarding intracellular redox state, DNA fragmentation, and apoptosis or necrosis profile. Jundishapur J Nat Pharm Prod. 2014 Nov 23;9(4):e20131.
70. Amin B, Abnous K, Motamedshariaty V, Hosseinzadeh H. Attenuation of oxidative stress, inflammation and apoptosis by ethanolic and aqueous extracts of Crocus sativus L. stigma after chronic constriction injury of rats. An Acad Bras Cienc. 2014 Dec;86(4):1821-32. (IF= 0.717 ).
71. Alibolandi M, Hadizadeh F, Vajhedin F, Abnous K*, Ramezani M. Design and fabrication of an aptasensor for chloramphenicol based on energy transfer of CdTe quantum dots to graphene oxide sheet. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:611-9. (IF= 3.420 )
72. Mokhtarzadeh A, Dolatabadi JE, Abnous K, de la Guardia M, Ramezani M. Nanomaterial-based cocaine aptasensors. Biosens Bioelectron. 2015 Jun 15;68:95-106. (IF=7.476)
73. Alibolandi M, Ramezani M, Sadeghi F, Abnous K*, Hadizadeh F. Epithelial cell adhesion molecule aptamer conjugated PEG-PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro. Int J Pharm. 2015 Feb 1;479(1):241-51. (IF= 3.994)
74. Razavi BM, Hosseinzadeh H, Imenshahidi M, Malekian M, Ramezani M, Abnous K*. Evaluation of Protein Ubiquitylation in Heart Tissue of Rats Exposed to Diazinon (an Organophosphate Insecticide) and Crocin (an Active Saffron Ingredient): Role of HIF-1α. Drug Res (Stuttg). 2015 Nov;65(11):561-6. (IF= 0.71 )
75. Taghdisi, S.M., Danesh, N.M., Lavaee, P., Emrani, A.S., Ramezani, M., Abnous, K*. A novel colorimetric triple-helix molecular switch aptasensor based on peroxidase-like activity of gold nanoparticles for ultrasensitive detection of lead(II) (2015) RSC Advances, 5 (54), pp. 43508-43514. (IF= 3.289 )
76. Taghdisi, S.M., Danesh, N.M., Lavaee, P., Sarreshtehdar Emrani, A., Ramezani, M., Abnous, K*. Aptamer Biosensor for Selective and Rapid Determination of Insulin (2015) Analytical Letters, 48 (4), pp. 672-681. (IF= 1.088 )
77. Rashedinia, M., Lari, P., Abnous, K*., Hosseinzadeh, H.Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain (2015) Acta Neurobiologiae Experimentalis, 75 (2), pp. 208-219. (IF= 1.708 )
78. Davari AS, Abnous K, Mehri S, Ghandadi M, Hadizadeh F. Synthesis and biological evaluation of novel pyridine derivatives as potential anticancer agents and phosphodiesterase-3 inhibitors. Bioorg Chem. 2014 Dec;57:83-9 (IF= 2.252 )
79. Verdian-Doghaei A, Housaindokht MR, Abnous Kh. A fluorescent aptasensor for potassium ion detection-based triple-helix molecular switch. Anal Biochem. 2014 Dec 1;466:72-5. (IF= 2.243 )
80. Alibolandi M, Abnous K, Ramezani M, Hosseinkhani H, Hadizadeh F. Synthesis of AS1411-aptamer-conjugated CdTe quantum dots with high fluorescence strength for probe labeling tumor cells. J Fluoresc. 2014 Sep;24(5):1519-29. (IF= 1.601 )
81. Dehghan S, Tafaghodi M, Bolourieh T, Mazaheri V, Torabi A, Abnous K, Tavassoti Kheiri M. Rabbit nasal immunization against influenza by dry-powder form of chitosan nanospheres encapsulated with influenza whole virus and adjuvants. Int J Pharm. 2014 Nov 20;475(1-2):1-8. (IF= 3.994)
82. Amin B, Hajhashemi V, Abnous K, Hosseinzadeh H. Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain. Biomed Res Int. 2014;2014:937568. (IF= 2.134 )
83. Verdian-Doghaei A, Housaindokht MR, Bozorgmehr MR, Abnous K. Conformational switch of insulin-binding aptamer into G-quadruplex induced by K(+) and Na(+): an experimental and theoretical approach. J Biomol Struct Dyn. 2014 Jun 16:1-41. [Epub ahead of print] PubMed PMID: 24933356. (IF=2.3) 84. Razavi MR, Malekian , Hosseinzadeh H, Ramezani M, Abnous K*, Evaluation of protein ubiquitylation in heart tissue of rats exposed to diazinon (an organophosphate insecticide) and crocin (an active saffron ingredients): Role of HIF-1. Drug Res (Stuttg). 2014 accepted. (IF= 0.71 ) 85. Taghdisi SM, Emrani SS, Tabrizian K, Ramezani M, Abnous K*, Emrani AS. Ultrasensitive detection of lead (II) based on fluorescent aptamer-functionalized carbon nanotubes. Environ Toxicol Pharmacol. 2014 May;37(3):1236-42. doi: 10.1016/j.etap.2014.04.020. Epub 2014 Apr 26. PubMed PMID: 24835552. (IF=2.187)
86. Ghorbani M, Mohamadpour AH, Mehri S, Abnous K*, Hassanzadeh-Khayyat M. Proteomics screening of molecular targets of granulocyte colony stimulating factor in the mouse brain and PC12 cell line. Life Sci. 2014. (IF= 2.685)
87. Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H. Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. Drug Res (Stuttg). 2014 Apr 2. [Epub ahead of print] PubMed PMID: 24696423. (IF= 0.71 )
88. Saberi, S., Eshghi, H., Rahimizadeh, M., Abnous, K. A New Versatile Route to the Synthesis of a Novel Series of Highly Substituted 1,1′-Carbonylbispyrazole Derivatives , Synlett., 2014,doi: 10.1055/s-0033-1340737 (IF=2.323)
89. Khodaverdi, E., Tafaghodi, M., Beizaei, S., Abnous, K., Alibolandi, M., Hadizadeh, F. Preparation and characterisation of PLGA-PEG-PLGA nanospheres prepared with a new thermogelling method for insulin delivery (2013) Journal of Chemical and Pharmaceutical Research 5 (10) PP. 311 - 319
90. Taghavi S, Ayatollahi S, Alibolandi M, Lavaee P, Ramezani M, Abnous K*, A novel label free cocaine assay based on aptamer-wrapped single-walled carbon nanotubes, Journal of Nanomedicine, Winter 2014, 1(2) 100-106
91. Lari P, Rashedinia M, Abnous K*, Hosseinzadeh H. Alteration of protein expression profile in rat liver cells exposed to subacute diazinon: A proteomic approach, Electrophoresis, May;35(10):1419-27. doi: 10.1002/elps.201300475. Epub 2014 Mar 24 (IF=2.482)
92. Razavi Rohani SS, Abnous K, Tafaghodi M. Preparation and characterization ofspray-dried powders intended for pulmonary delivery of Insulin with regard to the selection of excipients. Int J Pharm. 2014 (IF= 3.994)
93. Eshghi H, Rahimizadeh M, Saberi S, Abnous K and Bakavoli M, Pyrimido[5,4-e]tetrazolo[5,1-b][1,3,4]thiadiazines as a new heterocyclic System, Journal of Chemical Research, 2013 SEPTEMBER, 553–555 (IF= 0.661)
94. Vahdati Hassani F, Naseri V, Razavi BM, Mehri S, Abnous K, Hosseinzadeh H. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru. 2014 Jan 8;22(1):16. (IF= 1.654)
95. Firouzi Z, Lari P, Rashedinia M, Ramezani M, Iranshahi M, Abnous K*. Proteomics screening of molecular targets of curcumin in mouse brain. Life Sci. 2014 Jan 7;98(1):12-7. pii: S0024-3205(13)00970-3. doi: 10.1016/j.lfs.2013.12.200. [Epub ahead of print] PubMed PMID: 24394958. (IF= 2.685)
96. Hosseinzadeh H, Mehri S, Heshmati A, Ramezani M, Sahebkar A, Abnous K*. Proteomic screening of molecular targets of crocin. Daru. 2014 Jan 6;22(1):5. [Epub ahead of print] PubMed PMID: 24393168. (IF= 1.654)
97. Razavi BM, Hosseinzadeh H, Abnous K, Imenshahidi M. Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo. Drug Chem Toxicol. 2014 Jan 7. [Epub ahead of print] PubMed PMID: 24392635. . (IF= 1.653 )
98. Abnous K, Barati B, Mehri S, Masboghi Farimani MR, Alibolandi M, Mohammadpour F, Ghandadi M, Hadizadeh F. Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line. Daru. 2013 Dec 19;21(1):70. doi: 10.1186/2008-2231-21-70. PubMed PMID: 24355209; PubMed Central PMCID: PMC3891991. (IF= (IF= 1.654)
99. Lari P, Rashedinia M, Abnous K, Hosseinzadeh H. Crocin Improves Lipid Dysregulation in Subacute Diazinon Exposure through ERK1/2 Pathway in Rat Liver. Drug Res (Stuttg). 2013 Oct 16. [Epub ahead of print] PubMed PMID: 24132704. (IF= 0.71 )
100. Jalalian SH, Taghdisi SM, Shahidi-Hamedani N, Moosavian-Kalat SA, Lavaee P, ZandKarimi M, Ghows N, Jaafari MR, Naghibi S, Danesh NM, Ramezani M, Abnous K*, Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo. Eur J Pharm. Sciences, 2013 Oct 9;50(2):191-7 (accepted) (IF= 3.733)
101. Marzieh R, Hosseinzadeh H, Mohsen I, Parisa L, Bibi Marjan R, Khalil A*.Effect of exposure to diazinon on adult rat's brain. Toxicol Ind Health. 2013 Nov 11. (IF= 1.688)
102. Rezaee R, Mahmoudi M, Abnous K, Zamani Taghizadeh Rabe S, Tabasi N, HashemzaeiM, Karimi G. Cytotoxic effects of crocin on MOLT-4 human leukemia cells. J Complement Integr Med. 2013 (IF= 1.395 )
103. Shahidi-Hamedani N, Shier WT, Ariaee FM, Abnous K*, Ramezani M. Targeted gene delivery with non-covalent electrostatic conjugates of Sgc-8c aptamer and polyethylenimine. J Gene Med. 2013 (accepted) (IF= 3.246)
104. Behnam B., Abnous K*, Ramezani M*. Non-covalent functionalization of single-walled carbon nanotubes with modified polyethyleneimines for efficient gene delivery. International Journal of Pharmaceutics, 2013 15(6-7):261-9 (IF= 3.994)
105. Taghdisi SM, Danesh NM, Sarreshtehdar EA, Tabrizian K, ZandKarimi M, Ramezani M, Abnous K*, Targeted delivery of Epirubicin to cancer cells by PEGylated A10 aptamer, J Drug Target, 2013, (IF= 2.821)
106. Rashedinia M, Lari P, Abnous K*, Hosseinzadeh H. Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity. Toxicol Appl Pharmacol. 2013. (IF= 3.874)
107. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013 Jan;16(1):64-72. . (IF= 1.22 )
108. Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K*. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. 2013 May 25;203(3):547-55. (IF= 2.618)
109. Hosseinzadeh H, Mehri S, Abolhassani MM, Ramezani M, Sahebkar A, Abnous K*. Affinity-based target deconvolution of safranal. Daru. 2013 Mar 20;21(1):25. (IF= 1.654)
110. Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health. 2013 Feb 13. (IF= 1.688)
111. Taghiabadi E, Imenshahidi M, Abnous K, Mosafa F, Sankian M, Memar B, Karimi G. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evid Based Complement Alternat Med. 2012;2012:352091. (IF= 1.931)
112. Khodaverdi E, Tafaghodi M, Ganji F, Abnoos K, Naghizadeh H. In vitro insulin release from thermosensitive chitosan hydrogel. AAPS PharmSciTech. 2012 Jun;13(2):460-6. (IF= 1.954)
113. Amin B, Hajhashemi V, Hosseinzadeh H, Abnous Kh. Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat. Neuroscience. 2012 Nov 8;224:15-25. (IF= 3.231)
114. Ghorbani M, Moallem S, Abnous K, Tabatabaee Yazdi SA, Movassaghi AR, Azizzadeh M, Mohamadpour AH. The effect of granulocyte colony-stimulating factor administration on carbon monoxide neurotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):102-8. . (IF= 1.653 )
115. Abnous K, Dieni CA, Storey KB. Suppression of MAPKAPK2 during mammalianhibernation. Cryobiology. 2012 Dec;65(3):235-41. (IF= 1.920)
116. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012 Mar;32(2):227-35. (IF= 2.328)
117. Mohamadpour AH, Moallem SA, Hashemzaei M, Abnous K, Tabatabaee Yazdi SA, Imenshahidi M. Effects of granulocyte colony-stimulating factor on electrocardiogram changes after carbon monoxide poisoning in rats. Drug Chem Toxicol. 2012 Oct;35(4):353-60. . (IF= 1.653 )
118. Taghdisi SM, Lavaee P, Ramezani M, Abnous K*. Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. Eur J Pharm Biopharm. 2011 Feb;77(2):200-6. (IF= 3.975)
119. Taghdisi SM, Abnous K*, Mosaffa F, Behravan J. Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer. J Drug Target. 2010;18(4):277-81. (IF= 2.821)
120. Abnous K, Brooks SP, Kwan J, Matias F, Green-Johnson J, Selinger LB, Thomas M, Kalmokoff M. Diets enriched in oat bran or wheat bran temporally and differentially alter the composition of the fecal community of rats. J Nutr. 2009 Nov;139(11):2024-31. (IF= 3.74)
121. Abnous K, Storey KB. Skeletal muscle hexokinase: regulation in mammalian hibernation. Mol Cell Biochem. 2008 Dec;319(1-2):41-50. (IF= 2.613)
122. Abnous K, Dieni CA, Storey KB. Regulation of Akt during hibernation in Richardson's ground squirrels. Biochim Biophys Acta. 2008 Feb;1780(2):185-93. Epub 2007 Oct 22. Erratum in: Biochim Biophys Acta. 2010 Jul;1800(7):686. (IF= 5.083)
123. Abnous K, Storey KB. Regulation of skeletal muscle creatine kinase from a hibernating mammal. Arch Biochem Biophys. 2007 Nov 1;467(1):10-9. (IF= 2.807)
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Presentations |
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Abnous K. and Storey, K.B., The 44th Annual Meeting of Canadian Society of Zoologists, Queens University, Ontario, 10-14 May, 2005.
Abnous K., et al., AFMnet 4th Annual Scientific Conference, May 31st-June 3rd 2008, Vancouver, BC, Canada
Abnous K, Dieni CA, Storey KB. Experimental Biology, Washington, DC, April 28-May 2, 2007
Abnous K. and Storey, K.B., CRYO-2005, 42nd Annual Meeting of the Society for Cryobiology, Minneapolis, USA, July 24-27, 2005
Abnous K. and Storey, K.B., CFBS 48th annual meeting, University of Guelph, Guelph, Ontario, June 21-25,2005
Abnous K. and Storey, K.B., Protein Kinase Targets 2005, Cambridge Healthtech Institute. Boston. USA, Jun 6-7, 2005
Abnous K. and Storey, K.B., 7th Annual Chemistry & Biochemistry Graduate Research Conference, Concordia University, Montreal, November 14-15, 2004
Abnous K. and Storey, K.B., BioNorth 2004, Ottawa, November 29-December 1, 2004.
Abnous K. and Storey, K.B., 3rd International Conference of Comparative Physiology and Biochemistry in Africa: Animals and Environments, Ithala Game Reserve, KwaZulu-Natal, South Africa, August 7-13, 2004.
Abnous K. and Storey, K.B. 12th International Symposium, Vancouver, BC-Seward, Alaska, July 25-August 1, 2004.
Abnous K. and Storey, K.B., 6th Annual Chemistry & Biochemistry Graduate Research Conference, Concordia University, Montreal, November 14-15, 2003.
Abnous K. and Storey, K.B., BioNorth 2003, Ottawa, November 17-19, 2003.
Oral Presentations Abnous k., Ramezani M., Behravan J., Taghdisi S.M., Appilaction of Aptamers is Pharmaceutical Sciences, Nanotechnology Conference, 2008 Saberi M.R., Abnous K., Synthesis of 17, 21 dihydroxy progesterone, Iranian Organic Chemistry, 1997 |
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Honors & Awards |
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Members hip Membership |
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Administrative Responsibilities |
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Deputy of Education, Mashhad University of Medical Sciences |
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Other Skills |
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