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Dr. Alibolandi

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Dr. Mona Alibolandi

 

 

 

Assistant Professor of Medical Biotechnology

 

        [at]mums.ac.ir
[at]yahoo.com

  

Address: Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences

Tel/Fax: +98-51-37112470

 

alibolandim[at]mums.ac.ir

mona.alibolandi[at]gamil.com

Updated at: 30 June-2016                    

                                                       und Educational Background 

PhD in Research of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.

2011 to 2015

The title of my thesis was

"Synthesis of nanopolymerosome-anti EpCAM aptamer bioconjugates using PEG-PLGA copolymers for delivery of doxorubicin into cancer cells and evaluating their in vitro and  in vivo characteristics″

 

MSc in Microbial Biotechnology, Sciences and Research, Pasteur Institute of Iran, Tehran, Iran

2011-2013

The title of my thesis was

 “High level expression of human basic fibroblast growth factor in Escherichia coli”

 

                                                                   Research Interests

Self-assembled Polymeric Nanoparticles (Specially Polymersome and micelle structures)

Targeted drug delivery systems (Aptamers and small chemical molecules)

In vivo Tumor model for anti-cancer study (Mice and Nude mice)

Bioimaging (Synthesis of Quantum dots and inorganic molecules for MRI and CT imaging)

Oral Protein Delivery (Insulin), Diabetic Rat model

Graphene based materials

Recombinant proteins production and purification

                                                                       Publications
  1. Mona Alibolandi, Fatemeh Alabdollah, Fatemeh Sadeghi, Marzieh Mohammadi, Khalil Abnous, Mohammad Ramezani, Farzin Hadizadeh. Dextran-b-poly (lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation. J Control Release. 2016 Feb 21;227:58-70. (IF: 7.4)
  1. Mona Alibolandi, Mohammad Ramezani, Khalil Abnous*, Farzin Hadizadeh*. AS1411 aptamer-decorated biodegradable PEG-PLGA nanopolymersomes for the targeted delivery of gemcitabine to non-small cell lung cancer in vitro. 2016. J Pharm Sci. 2016 May;105(5):1741-50.  (IF: 2.69)
  1. Mona Alibolandi, Khalil Abnous, Hossein Hosseinkhani, Mohammad Ramezani*, Farzin Hadizadeh*. Folate Receptor-Targeted Multimodal Polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: in vitro and in vivo Evaluation. Int J Pharm. 2016 Mar 16;500(1-2):162-78. (IF:3.99)

 
  1. Elham Khodaverdi, Marzieh Gharechahi, Mona Alibolandi, Farnaz Sadat Mirzazadeh Tekieh, Bibi Zahra Khashayarmanesh, Farzin Hadizadeh. Self-assembled supramolecular hydrogel based on PCL-PEG-PCL triblock copolymer and γ-cyclodextrin inclusion complex for sustained delivery of dexamethasone. Journal of Pharmaceutical Investigation. 2016; 6(2): 78-85. (PUBMED)

 
  1. Sara Ayatollahi, Maryam Hashemi, Reza Kazemi Oskuei, Zahra Salmasi, Ahad Mokhtarzadeh, Mona Alibolandi, Khalil Abnous, Mohammad Ramezani. Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells. J Biomater Appl. 2015 Nov;30(5):632-48. (IF: 2.19)

 
  1. Mona Alibolandi, Fatemeh Sadeghi, Khalil Abnous, Fatemeh Atyabi, Mohammad Ramezani*, Farzin Hadizadeh*. The chemotherapeutic potential of doxorubicin loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model. European Journal of Pharmaceutics and Biopharmaceutics. 2015. 94: 521–531. (IF: 3.9)

 
  1. Mona Alibolandi, Mohammad Ramezani, Khalil Abnous, Fatemeh Sadeghi, Fatemeh Atyabi, Mohsen Asouri, Ali Asghar Ahmadi, Farzin Hadizadeh. In Vitro and In Vivo Evaluation of Therapy Targeting Epithelial-cell Adhesion-molecule Aptamers for non-Small Cell Lung Cancer. Journal of Controlled Release. 2015. 209:88-100. (IF: 7.4)

 
  1. Mona Alibolandi, Mohammad Ramezani, Khalil Abnous, Fatemeh Sadeghi, Farzin Hadizadeh. Comparative evaluation of polymersome versus micelle structures as vehicles for the controlled release of drugs. Journal of Nanoparticle Research. 2015. 17:76. (IF:2.18)

 
  1. 9.      Mona Alibolandi, Fatemeh Sadeghi, Seyed Mohammad Sazmand, Seyed Mohammad Shahrokhi, Farzin Hadizadeh. Synthesis and self-assembly of biodegradable PEG-PLA diblock copolymers as polymersomes for preparation of sustained release system of doxorubicin. International Journal of Pharmaceutical Investigation. 2015. 5(3):134. (PUBMED)

 
  1. Mona Alibolandi, Farzin Hadizadeh, Fereshteh Vajhedin, Khalil Abnous, Mohammad Ramezani. Design and fabrication of an aptasensor for chloramphenicol based on energy transfer of CdTe quantum dots to graphene oxide sheet. Materials Science and Engineering C. 2015; 48C: 611-619. (IF: 3.4)

 
  1. Mona Alibolandi, Mohammad Ramezani, Fatemeh Sadeghi, Khalil Abnous, Farzin Hadizadeh. Epithelial cell adhesion molecule aptamer conjugated PEG–PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro. International Journal of Pharmaceutics. 2015; 479(1): 241-251. (IF: 3.99)

 
  1. Mona Alibolandi, Khalil Abnous, Mohammad Ramezani, Hossein Hosseinkhani, Farzin Hadizadeh (2014) Synthesis of AS1411-aptamer-conjugated CdTe quantum dots with high fluorescence strength for probe labeling tumor cells. J Fluoresc. 2014 Sep;24(5):1519-29. (IF: 1.92)

 
  1. Khodaverdi E, Heidari Z, Tabassi SA, Tafaghodi M, Alibolandi M, Tekie FS, Khameneh B, Hadizadeh F. Injectable Supramolecular Hydrogel from Insulin-Loaded Triblock PCL-PEG-PCL Copolymer and γ-Cyclodextrin with Sustained-Release Property. AAPS PharmSciTech. 2014 Sep 16. (IF: 1.8)

 
  1. Maryam Iman, Asghar Davood, Bert Klein Gebbink, Parisa Azerang, Mona Alibolandi, Soroush Sardari. Design and Antimicrobial Evaluation of 1-Methylimidazole Derivatives as New Antifungal and Antibacterial Agents. Pharmaceutical Chemistry Journal, 2014; 48(8):513-519. (IF: 0.46)

 

 
  1. Khodaverdi E, Honarmandi R, Alibolandi M, Baygi RR, Hadizadeh F, Zohuri G. Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs. Iran J Basic Med Sci. 2014 May;17(5):337-43. (IF: 1.22)

 
  1. Seyed Adel Moallem, Niloufar Dehghan, Soghra Mehri, Shabnam Shahsavand, Mona Alibolandi, Farzin Hadizadeh. Synthesis of four novel 1, 8-acridinediones derivatives: Investigation of MDR reversibility in breast cancer cell lines T47D and tomoxifen-resistant T47D. Research in Pharmaceutical Science. 2015. 10(3):214-221. (IF: 0.6)

 
  1. Moallem SA, Imenshahidi M, Shahini N, Javan AR, Karimi M, Alibolandi M, Ghandadi M, Etemad L, Motamedshariaty V, Hosseini T, Hadizadeh F. Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors. Iran J Basic Med Sci. 2013 Dec;16(12):1238-44. (IF:1.22)

 
  1. Abnous K, Barati B, Mehri S, Masboghi Farimani MR, Alibolandi M, Mohammadpour F, Ghandadi M, Hadizadeh F. Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line. Daru. 2013 Dec 19;21(1):70. (IF: 1.64)

 
  1. Khodaverdi E, Tafaghodi M, Beizaei S, Abnous K, Alibolandi M, Hadizadeh F. Preparation and characterisation of PLGA-PEG-PLGA nanospheres prepared with a new thermogelling method for insulin delivery Journal of Chemical and Pharmaceutical Research, 2013, 5 (10): 311-319. (Scopus)

 
  1. Sahar Taghavi, Sara Ayatollahi, Mona Alibolandi, Parirokh Lavaee, Mohammad Ramezani, Khalil Abnous. A novel label free cocaine assay based on aptamer-wrapped single-walled carbon nanotubes. Nanomedicine Journal. 01/2013; 1(2):105-111. (ISC, Chemical abstract)

 
  1. Mona Alibolandi and Hasan Mirzahoseini (2011) Purification and refolding of over-expressed human basic Fibroblast Growth Factor in Escherichia coli. Biotechnology research International, Volume 2011, Article ID 973741, 1-6. (Pubmed)

 
  1. Mona Alibolandi, Hasan Mirzahoseini, Mehri Abedi Khalil Abad, Mehrnaz Azami Movahed (2010) High level expression of human basic Fibroblast Growth Factor in Escherichia coli: Evaluation the effect of the GC content and rare codons within the first 13 codons. African Journal of Biotechnology. 9(16), 2456-2462. (IF: 0.58)

 
  1. Mona Alibolandi, Hasan Mirzahoseini, Farzaneh Moshtaghi Nehi, Golnaz Tabatabaian, Hossein Amini, Soroush Sardari (2010) Improving recombinant protein solubility in Escherichia coli: Identification of best chaperone combination which assists folding of Human basic Fibroblast Growth Factor. African Journal of Biotechnology. 9 (47), pp. 8100-8109. (IF:0.58)

 
  1. Hasan Mirzahoseini and Mona Alibolandi (2009) Stability of recombinant proteins in Escherichia coli: the effect of co-expression of five different chaperone sets. J. Sciences of Islamic Republic of Iran. 20(4) 305-310. (ISI)

 
  1. Amir Amanzadeh, Mona Alibolandi, Mojgan Khayat Moghadam, Hasan Mirzahoseini (2009) Comparative study of recombinant versus natural hbFGF in survival and proliferation of primary cultured 3T3 cells. Microorganisms in industry and environment from Scientific and Industrial Research to Consumer Products (pp 543-545)

 

 

 

 

 

Presentations
  1. Mona Alibolandi, Khalil Abnous, Mohammad Ramezani, Farzin Hadizadeh (2016) Targeted Multimodal Doxorubicin-Quantum dots loaded PEG-PLGA polymersomes for Targeted Cancer Therapy and Imaging. ICNS6, Kish, 6-9 March.

 
  1. Mona Alibolandi, Fatemeh Alabdollah, Farzin Hadizadeh (2015) Synthesis of polysaccharide-polyester nanopolymersomes for oral delivery of insulin. The 3rd International Congress on Nanoscience and Nanotechnology, Istanbul, Turkey, 2-3 July.

 
  1. M Aliboladi, F Hadizadeh, F Sadeghi, S H Sazmand, S M Shahrokhi (2014) Synthesis and self assembly of biodegradable PEG-PLA diblock copolymers as polymersomes. ICNS5, Kish, 6-9 March
  2. M Alibolandi, K Abnous, M Ramezani, F Hadizadeh (2014) Aptamer conjugated polymersome-encapsulated QDs for cancer cell targeting and imaging, ICRC2014,25-27 Feb, TEHRAN

 
  1. M Alibolandi, F Sadefghi, F Hadizadeh (2014) Self-assemble PEG-PLA polymersomes for sustained delivery of doxorubicin, ICRC2014,25-27 Feb, TEHRAN

 
  1. Farzin Hadizadeh, Mona Alibolandi (2013) Highly luminescence, microwave assisted synthesis of water soluble carboxylic acid-functionalized CdTe Quantum Dots. 19th Iranian Seminar of Analytical chemistry 26-28 Feb. Mashhad, Ferdowsi University

 
  1. Mona Alibolandi and Hasan Mirzahoseini. Artificial chaperones: Gold nanoparticles assisted refolding of human basic Fibroblast Growth Factor. Abstract book of IV International conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2011). Torremolinos (Spain), 14-16 September 2011.

 

  1. Amir Amanzadeh, Mona Alibolandi, Mojgan Khayat Moghadam, Hasan Mirzahoseini* (2009) Comparative study of recombinant versus natural hbFGF in survival and proliferation of primary cultured 3T3 cells. III International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2009) Lisbon, Portugal, 2 – 4 December 2009.

 
  1. Mona Alibolandi and Hasan Mirzahoseini. TIR modification and over-expression of human basic Fibroblast Growth Factor in Escherichia coli. Proceeding of 15th national and 3rd international conference of biology. 19-21 august 2008, Tehran-Iran. Page: 287.

 
  1. Hasan Mirzahoseini, Mona Alibolandi, Samaneh Mafakeri. Evaluation of different host strains for the high level expression of human basic Fibroblast Growth Factor in Escherichia coli. Proceeding of 15th national and 3rd international conference of biology. 19-21 august 2008, Tehran-Iran. Page:109

                                                                    Honors & Awards
  • Talented young researcher which candidate from Iran National Foundation for attendance in Asian Nano Camp 2016, Vienna, Austria.

 
  • The first rank between PhD by research students in the research week festival, Mashhad University of Medical Sciences (2015).

 

 
  • Best PhD thesis award by the Ministry of Health and Medical Education of Iran, 2015. (125,000,000 Rials)

 
  • Grant for PhD thesis from Iran National Foundation, 2011. (340,000,000 Rials)

 

 

 

                                                           Administrative Responsibilities

Assistant Prof. of Nanomedicine laboratory, Pharmaceutical Research Center,

Mashhad University of Medical Sciences