Dr. Hossein Hosseinzadeh

Professor of Pharmacology

        [at]mums.ac.ir
[at]yahoo.com

Address: School of Pharmacy, MUMS, 1365-91775, Mashhad, Iran

Tel:00985138819042

Fax:00985138823251

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Updated at:                           

                                                       Educational Background 

Pharm.D: School of Pharmacy, Mashhad, Iran

Ph.D.: Department of Pharmacology, Glasgow, Scotland

                                                                   Research Interests

Ethnopharmacology

Neuropharmacology

Behavioral study

Herbal Medicine

Enviromental Toxicology

                                                                       Publications

1-HOSSEINZADEH, H. & STONE, T. W. (1994). The effect of calcium removal on the suppression by adenosine of epileptiform activity in the hippocampus: demonstration of desensitization. Br. J. Pharmacol., 112, 316-322.

2-HOSSEINZADEH, H. & STONE, T. W. (1994). Mechanism of the hippocampal loss of adenosine sensitivity in calcium-free media. Brain Res., 569, 221-225.

3-HOSSEINZADEH, H. & STONE, T. W. (1994). A paradoxical inhibitory effect of xanthines on hippocampal excitability in calcium-free media. Brain Res., 567, 300-306.

4-HIGGINS, M. J., HOSSEINZADEH, H., MACGREGOR, D. G., OGILVY, H. & STONE, T. W. (1994). Release and actions of adenosine in the central nervous system. Pharm. World Sci., 16, 62-68.

5-HOSSEINZADEH, H. & STONE, T. W. (1996). Adenosine in the central nervous system. Med. J. Isl. Rep. Iran., 9, 361-368.

6-HOSSEINZADEH, H. & STONE, T. W. (1998). Tolbutamide blocks postsynaptic but not presynaptic effects of adenosine on hippocampal CA1 neurons. J. Neural. Transm., 105, 161-172.

7-HOSSEINZADEH, H. & SHOOSHTARI, M. E. (1999).Antinociceptive interaction between adenosine and carbamazepine in mice. Med. J. Isl. Rep. Iran., 12, 381-386.

8-HOSSEINZADEH, H., HADDADKHODAPARAST, M.H &  SHOKOOHIZADEH, H. (1998). Antihyperglycemic effect of Salvia leriifolia Benth. leaf and seed extract in mice. Irn. J. Med. Sci.23, 74-80.

9-HOSSEINZADEH, H. & DEHGHAN, R. (1999). Anti-inflammatory effects of methylxanthines in some models of acute and chronic inflammation in mice and rats. Pharmac. Pharmacol. Lett. 9, 18-19.

10-HOSSEINZADEH, H. & RAHIMI, R. (1999). Anti-inflammatory effects of Elaeagnus angustifolia. Irn. J. Med. Sci., 24, 143-147.

11-HOSSEINZADEH, H. & YAVARI, M. (1999). Anti-inflammatory effects of Salvia leriifolia Benth. leaf extract in mice and rats. Pharmac. Pharmacol. Lett., 9, 60-61.

12-HOSSEINZADEH, H. & SADEGHI, A. (1999). Antihyperglycemic effects of Morus nigra and Morus alba in mice. Pharmac. Pharmacol. Lett., 9, 63-65.

13-HOSSEINZADEH, H. & DINDAR, A. H. (1999). Antinociceptive effects of the aerial parts of Mentha piperita and Mentha pulegium extract in mice. Irn. J. Basic Med. Sci., 2, 1-7.

14-HOSSEINZADEH, H. & FADISHEI, M. (2000). Circadian variation of the acute toxicity and nociceptive activity of aminophylline in mice. Med. J. Isl. Rep. Iran., 13, 287-290.

15-HOSSEINZADEH, H. & TAHERI, M. R. (2000). Antinociceptive effects of Elaeagnus angustifolia in mice . Med. J. Isl. Rep. Iran., 14, 77-81.

16-HOSSEINZADEH, H. & LARI, P. (2000). Effect of Salvia leriifolia extract on morphine dependence in mice . Phytotherapy Res. 14, 384-387.

17-HOSSEINZADEH, H. & RAMEZANI, M. & SALMANI, G. (2000). Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora  Boiss extract in mice and rats. J. Ethnopharmacol. 73, 379-385.

18-HOSSEINZADEH, H. & AMEL, S. (2000). Antinociceptive effects of the aerial parts of Salvia nemorosa L. extracts in mice. Arch. Irn. Med. 3, 81-84.

19-HOSSEINZADEH, H & MADANIFARD, M. (2000). Anticonvulsant effect of Coriandrum sativum L. seeds extracts in mice. Arch. Irn. Med. 3, 3, 182-184.

20-HOSSEINZADEH, H., HADDADKHODAPARAST, M.H. & HOSSEINI, E. (2000). Anti-ulcer effect of Salvia leriifolia Benth. leaf extracts in mice. Pharmac. Pharmacol. Lett., 2, 63-64.

21-HOSSEINZADEH, H. & AMEL, S. (2001). Antinociceptive effects of the aerial parts of Perovskia abrotanoides extracts in mice. Med. J. Iran Hosp. 4, 15-17.

22-HOSSEINZADEH, H & ARABSANAVI, J. (2001). Anticonvulsant effect of Salvia leriifolia Bentm. seed and leaf extracts in mice. Irn. J. Basic Med. Sci., 3, 163-170.

23-RAMEZANI, M., HOSSEINZADEH, H. & DANESHMAND. N. (2001). Antinociceptive effect of Elaegnus angustifolia fruit seeds in mice. Fitoterapia, 72, 255-262.

24-RAMEZANI M., HOSSEINZADEH, H. & MOJTAHEDI. K. (2001). Effect of Ferula gommosa Bioiss. fractions on morphine dependence in mice. J. Ethnopharmacol. 77, 71-75.

25-HOSSEINZADEH, H., FAZLY BAZZAZ, B.S. & AHMADZADEH, S. (2001). In vitro evaluation of methylxanthines and some antifungal drugs: interaction against Candida albicans.  Pharmac. Pharmacol. Lett., 11, 34-36.

26-KARIMI, G., HOSSEINZADEH, H. and KHALEGHPANAH, P. (2001). Study of antidepressant effect of aqueous and ethanolic extract of Crocus  sativus in mice. Irn. J. Basic Med. Sci., 4, 11-15.

27-HOSSEINZADEH, H & KHOSRAVAN, V. (2002). Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch. Irn. Med. 5, 44-47.

28-HOSSEINZADEH, H. RAMEZANI, M. FADISHEI, M. & MAHMOUDI, M (2002). Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria  majdae extract in mice and rats. Phytomedicine. 9, 135-141.

29-HOSSEINZADEH, H., RAMAZANI, M. & DANAEI, A. R. (2002). Antihyperglycemic effect and acute toxicity of  Securigera securidaca L. seed extracts in mice. Phytotherapy Res. 16, 745-747.

30-HOSSEINZADEH, H. & YOUNESI, H. (2002). Petal and stigma extracts of Crocus  sativus L. have antinociceptive and anti-inflammatory effects in mice. BMC Pharmacol., 2, 7.

31-HOSSEINZADEH, H,  KARIMI, G. & AMERI, M (2002). Anti-ulcer and acute toxicity effects of Anethum graveolens L. seed extracts in mice. BMC Pharmacol. 2:21.

32-HADIZADEH, F., HOSSEINZADEH, H., MEHRABI, M. (2002). Anticonvulsant effects of non-benzodiazepine BZR ligand benzylimidazolylthiadiazolidine in mice.        Medicinal/Pharmaceutical Chemistry (2002), 1-5.

33-HOSSEINZADEH, H. & SADATI, N. (2003). The protective effect of Allium sativum L. cloves aqueous and methanolic extracts against hypoxia-induced lethality in mice. Phytotherapy Res. 17, 279-281.

34-KHOEI, A-R., HOSSEINZADEH, H & IMANSHAHID, M. (2003). Patological evaluation of anti-ischemic effect of Salvia leriifolia Benth. seed and leaf extracts in rats after global cerebral ischemia. Irn. J. Basic Med. Sci., 5: 8-13.

35-HOSSEINZADEH, H & HATAMI, M. (2003). Antinociceptive effect of adenosine A1 receptor agonist, R-phenylisopropyladenosine, in diabetic mice. Med. J. Iran Hosp. 5. 19-23.

36-HOSSEINZADEH, H,  RAMEZANI, M & NAMJO, N. (2003).  Muscle relaxant activity of Elaeagnus angustifolia fruit seeds in mice . J. Ethnopharmacology. 84, 275-278.

37-HOSSEINZADEH, H., HADDADKHODAPARAST, M.H. & ARASH, A. (2003). Antinociceptive, anti-inflammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats. Phytotherapy Res. 17, 422-425.

38-HOSSEINZADEH, H. & NOURBAKHSH. M. (2003). Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice. Phytotherapy Res.17, 938-941.

39-HOSSEINZADEH, H. & NASSIRI M. A. (2003). Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacol. 3: 1.

40-HOSSEINZADEH, H. & PARVARDEH, S. (2004). Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 11: 56-64.

41-RAMEZANI M, HOSSEINZADEH, H.,  SAMIZADEH S. (2004). Antinociceptive effects of Zataria multiflora Boiss fractions in mice. J. Ethnopharmacol. 91:167-70.

42-HOSSEINZADEH, H., KARIMI, G-R &  NIAPOOR. M. (2004). antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. Acta Hort. (ISHS) 650:435-445

43-KARIMI, G., HOSSEINZADEH, H. & ETTEHAD,N. (2004). Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice. Phytother. Res. 18: 484-487.

44-HOSSEINZADEH, H,  MEHRABI, M. & GHORBANI A. (2004) Anti-emtic effect of Mentha piperita aerial parts extract in young chickens. IJPS. 1: 21-25

45-HOSSEINZADEH, H.,  NASSIRI ASL, M., & PARVARDEH, S.,  MANSOURI, M. T. (2005). The effects of carbenoxolone on spatial learning in Morris water maze task in rats. Med. Sci. Monit. 11: BR. 88-94.

46-HOSSEINZADEH, H.,  PARVARDEH, S., NASSIRI ASL, M. and  MANSOURI, M. T. (2005). Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. MedSci Monit, 11. BR106-110.

47-HOSSEINZADEH, H.,  NASSIRI ASL, M., & PARVARDEH, S.,  (2005). The effect of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal muscle and hippocampus of rats. Phytomedicine. 12: 632-637.

48-HOSSEINZADEH, H,  KARIMI, G. & RAKHSHANIZADEH, M (2005). anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum, role of nitric oxide. J. Ethnopharmacol. 98: 207-208.  

49-HOSSEINZADEH, H,  RAMEZANI, M & HAGHGOO, A. (2005). Antinociceptive Effects of Melisa officinalis aerial parts extracts in mice. MJIRC. 8: 7-12.

50-MANSOURI, M. T., NAGHIZADEH, B. and HOSSEINZADEH, H. (2005). The effect of Pistacia vera L. gum extract on oxidative damage during experimental cerebral ischemia-reperfusion in rats. Ir. Biomed. J. 9: 181-185.

51-HADIZADEH, F, KHALILI, N., HOSSEINZADEH, H. AND KHAIR-ALDINE, R. (2003). Kaempferol from saffron petals. Irn. J Pharmac. Res. 2: 251-252.

52-HOSSEINZADEH, H., SADEGHNIA, H.R., ZIAEE, T. AND DANAEE, A. (2005).Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J. Pharm. Pharmacol. Sci. 8: 387-393.

53- HOSSEINZADEH, H. and SADEGHNIA, H.R. (2005). Safranal, a constituent of Crocus sativus (saffron) attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J. Pharm. Pharmacol. Sci. 8:394-399.

54- Hosseinzadeh, H. and Talebzadeh, F. (2005). Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia. 76: 722-724.

55- Jaffari, M. R., Malaekeh-Nikouei, B. Nasirli, H. and Hosseinzadeh, H. (2005). Formulation of topical encapsulated with triamicilone and comparison of their anti-inflammatory effects with available conventional topical ointment in mice. Irn. J. Basic Med. Sci. 8: 195-201.

56-Hosseinzadeh, H. and Ghenaati, J. (2006). Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus L.) and its components, safranal and crocin in guinea pigs. Fitoterapia 77, 446-448.

57-Hosseinzadeh, H and Ziaee, T. (2006). Effect of Nepeta glomerulosa Boiss. aerial parts aqueous extract on morphine withdrawal syndrome in mice. IJPS. 2, 119-130.

58-Hosseinzadeh, H., Jaafari, M-R., Khoei, A-R. and Rahmani, M. (2006). Anti-ischemic effect of Nigella sativa L. seed in male rats. IJPR. 1: 53-58.

59-Imanshahidi, M. and Hosseinzadeh, H. (2006).The pharmacological effects of Salvia species on the central nervous system. Phytother. Res. 20:427-37.

60-Hosseinzadeh, H., Fazly Bazzaz, B.S. & Sadati, M. M. (2006). In vitro evaluation of methylxanthines and some antibiotics: interaction against Staphylococcus aureus and Pseudomonas aeruginosa. Iran Biomed J. 10: 163-167.

61-Sajadi Tabassi, S.A., Hosseinzadeh, H, Ramezani, M., Moghimipour, E., Mohajeri, S.A.  (2006). Isolation, characterization and study of enhancing effects on nasal absorption of insulin in rat of the total saponin from Acanthophyllum squarrosum. Curr. Drug Deliv. 3: 399-404.

62-Hosseinzadeh, H. and Sadeghnia, H-R. and (2007). Protective effect of safranal, an active constituent of Crocus sativus, on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems. Phytomedicine. 14: 256-262.

63-Hosseinzadeh, H., Ziaee, T. and Ahi, A. (2007). Effect of Marrubium vulgare L. Aerial Parts Aqueous and Ethanolic Extracts on Morphine Withdrawal Syndrome in Mice. Pharmacologyonline 3: 422-427.

64-Hosseinzadeh, H and Montahaei, R. (2007). Protective effect of Nigella sativa l. extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. Pharmacologyonline. 1:176-189.

65-Nassiri-Asl, M., Hosseinzadeh, H. and Mortazavi, S. R. (2007). Effects of Berberis vulgaris fruit extracts and its active omponent, berberine, on morphine dependence, hypnosis and locomotor activity in mice. Pharmacologyonline. 1: 190-202.

66-Hosseinzadeh, H., Parvardeh, S., Asl, M.,  Sadeghnia, H. R. and Ziaee^, T. (2007). Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine. 14:621-627.

67-Hosseinzadeh, H., Hosseini, A., Nassiri-Asl, M. and Sadeghnia, H-R. (2007). Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle. BMC Complemen. Alter. Med. 7:23.

68-Hosseinzadeh, H., Fazly Bazzaz, B.S. and Haghi, M. M. (2007). Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice. Pharmacologonline. 2: 429-435.

69-Hosseinzadeh, H., Moghim, F. F. and Mansouri, S. M. T. (2007). Effect of Nigella sativa seed extracts on ischemia-reperfusion in rat skeletal muscle. Pharmacologyonline. 2:326-335.

70-Hosseinzadeh, H. and Shariaty, V. M. (2007). Anti-nociceptive effects of safranal, a constituent of Crocus sativus (saffron), in mice. Pharmacologyonline. 2: 498-503.

71-Hosseinzadeh, H., Motamedshariaty, V. and Hadizadeh, F. (2007). Antidepressant effect kaempferol, a constituent of saffron (crocus sativus) petal, in mice and rats. Pharmacologyonline. 2: 367-370.

72-Jaafari, M. R., Hooshmand, S., Samiei, A. and Hosseinzadeh, H. (2007). Evaluation of leishmanicidal effect of Perovskia abrotanoides Karel. root extract by in vitro leishmanicidal assay using promastigotes of Leishmania  major. Pharmacologyonline. 1: 299-303.

73-Sadeghnia, H-R. and Hosseinzadeh, H. (2007). Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mice organs: An alkaline single cell gel electrophoresis (comet) assay. DNA Cell Biol. 26: 841-6.  

 
74-Imenshahidi, M, Hosseinzadeh, H. And Es'haghian, A.  (2007). Effects of ethosuximide on morphine tolerance and dependence in mice. Pharmacologyonline.  2: 287-299.

75-Moallem, S. A., Hosseinzadeh, H. and Ghoncheh, F. (2007). Evaluation of antidepressant effects of aerial parts of Echium vulgare in mice. Irn. J. Basic Med. Sci. 10, 189 – 196

76-Hadizadeh, F., Hosseinzadeh, H., Motamed-Shariaty, V-S., Seifi, M and Kazemi, S. (2008). Synthesis and antidepressant activity of N-substituted imidazole-5-caboxamides in forced swimming test model. IJPR. 7:29-33.

77-Asl, M.N. and Hosseinzadeh, H. (2008).  Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res. 22:709-24.

78-Hosseinzadeh, H., Ziaee, T. and Sadeghi, A. (2008). Effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors of normal male rats. Phytomedicine. 15: 491-5.

79-Sadeghnia HR, Cortez MA, Liu D, Hosseinzadeh H. and Snead 3rd OC (2008). Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography. J. Pharm. Pharmac. Sci. 11: 1-14.

80-Imanshahidi, M. and Hosseinzadeh, H. (2008). Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother. Res. 22: 999-1012.

81-Modaghegh, M-H., Shahabian, M. Esmaeili, H-A. Rajbai, O and Hosseinzadeh, H. (2008). Safety evaluation of saffron, Crocus sativus, tablet in healthy volunteers. Phytomedicine. 15:1032-1037.

82-Hosseinzadeh, H., Jaafari, M. R. and Shamsara , J. (2008). Selective inhibitory effect of adenosine A₁ receptor agonists on the proliferation of human tumor cell lines. Iran Biomed J. 12: 203-208..

83-Hosseinzadeh, H. Sadeghnia, H. R and Rahimi, A. (2008). Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic acid treatment in anesthetized rats. Planta Med. 74:1441-5.

84-Hosseinzadeh, H., Mirshojaeian, M. and Razavi, B. M. (2008).  Antiemetic effect of Pistacia vera L. (Pistachio) leaves and nuts aqueous extracts in young chicken. Pharmacologyonline. 2, 568-571.

85-Hosseinzadeh, H.,  Abootorabi, A. and Sadeghnid, H. R. (2008). Protective effect of Crocus sativus stigmas extract and crocin (trans-crocin 4) on methyl methanesulfonate (MMS)-induced DNA damage in mice organs. DNA Cell. Biol. 27, 657-664

86-Moallem, S.A., Hosseinzadeh, H and Farahi, S. (2008). A study of acute and chronic anti-nociceptive and anti-inflammatory effects of thiamine in mice. Iran Biomed J. 12:173-8.

87-Hosseinzadeh, H., Eskandari, M.and Ziaee, T. (2008). Antitussive effect of thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs. Pharmacologyonline. 2: 480-484.

88-Hosseinzadeh, H., Dowlati, S. and Etemad, L. (2008). Effects of Stachys byzantina C. Koch aerial parts aqueous extract on morphine dependence and tolerance in mice. Pharmacologyonline. 2:614-617.

89-Hadizadeh F., Ebrahimzadeh M. A., Hosseinzadeh H., Motamed-Shariaty V., Salami, S. and  Bekhradnia A. R. (2009). Antidepressant and antioxidant activities of some 2-benzoxazolinone derivatives as bupropion analogues. Pharmacologyonline 1: 331-335

90- Hosseinzadeh, H., Sadeghnia, H.R., Imenshahidi, M. and Fazly Bazzaz, B. S. (2009). Review of the pharmacological and toxicological effects of Salvia leriifolia. Irn. J. Basic Med. Sci. 12: 1-8.

91-Nassiri-Asl, M. and  Hossein Hosseinzadeh, H. (2009). Review of the pharmacological effects of Vitis vinifera (grape) and its bioactive compounds. Phytother. Res. 23, 1197-204.

92-Hosseinzadeh, H. and Noraei, N. B. (2009). Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother. Res. 23: 768-774.

93-Hosseinzadeh, H. and Mehrabi. (2009). Effect of R-phenylpropyladenosine and methylxanthines on memory and learning performance in goldfish. Pharmacologyonline. 2: 686-689.

94-Shamsa, A. Hosseinzadeh, H. Molaei, M., Shakeri, M.T. and Rajabi, O. (2009). Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study.Phytomedicine. 16: 690-693.

95-Hosseinzadeh, H., Modaghegh, M. H. and Saffari, Z. (2009). Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. eCAM. 6: 343–350.

96-Hosseinzadeh, H.,Motamedshariaty, V. S. and Ziaee, S. T. (2009). Protective effect of of Salvia leriifolia Benth. root aqueous and ethanolic extracts on renal ischemia-reperfusion in uninephrectomized Wistar male rats. Pharmacologyonline. 2: 651-655.

97-Ebrahimzadeh, M. A., Hadizadeh, F. Hosseinzadeh, H., Hajipoor, M. and Nabavi, S. M. (2009). Antioxidant and antidepressant effects of four  novel bupropion  analogues.  Pharmacologyonline 2: 317-322

98-Hosseinzadeh, H., Shamsaie, F. and  Mehri, S. (2009). Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus l. stigma and its bioactive constituent, crocin and safranal. Pharmacog. Mag. 5: 419-424.

99-Hosseinzadeh, H., Sayadi, S. K., Taghiabadi, E. and Razavi, B. M. (2009).  Anticonvulsant effect of Citrus Bigaradia Duh. Leaves extract in mice. Pharmacologyonline 3: 412-418.

100-Hosseinzadeh, H., Fadishei, M., Taghiabadi, E. and Razavi, B. M. (2009).  Circadian variation of antinociceptive effect of adenosine and adenosine A1 receptor agonists, N6-phenylisopropyl adenosine and 2-chloroadenosine, in mice. Pharmacologyonline 3: 539-543.

101-Hosseinzadeh, H. and Jahanian, Z. (2010). Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother. Res. 24,726-30.

102-Golmohammadzadeh, S., Jaafari, M. R. and Hosseinzadeh, H. (2010). Does saffron have antisolar and moisturing effect? Irn. J. Pharmac. Res. 9:133-140.

103-Mohajeri, S. A. Hosseinzadeh, H.  Keyhanfar, F. and  Aghamohammadian, J. (2010). Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction. J. Sep. Sci. 33, 1–8

104-Hosseinzadeh, H., Khooei, A-R., Khashayarmanesh, Z. and Motamed-Shariaty, V. (2010). Antiurolithiatic Activity of Pinus eldarica Medw. Fruits Aqueous Extract in Rats. Urology J. 7:232-7.

105- Imenshahidi M, Hosseinzadeh H, Javadpour Y. (2010). Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res. 24, 990-994.

106-Karimi, G., Hosseinzadeh, H., Rassoulzadeh, M. Razavi, B. M. and Taghiabadi, E. (2010) Antinociceptive effect of Elaeagnus angustifolia fruits on sciatic nerve ligated mice.  Irn. J. Basic Med. Sci. 13, 97-101.

107-Behnam-Rassouli, M., Aliakbarpour, A., Hosseinzadeh, H., Behnam-Rassouli, F., and Chamsaz,  M. (2010). Investigating the effect of aqueous extract of Chicorium intybus L. leaves on offspring sex ratio in rat. Phytother Res. 2010. 24, 1417-21

108-Hariri, A.T., Moallem, .A., Mahmoudi, M., Memar, B., Hosseinzadeh, H.  (2010). Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective. effects of crocin and safranal. Food Chem. Toxicol. 48, 2803-8

109-Hosseinzadeh, H., Shariaty, M. V., Sameni, A. K. and Vahabzadeh, M. (2010). Acute and sub-acute toxicity of crocin, a constituent of Crocus sativus L. (saffron), in mice and rats. Pharmacologyonline 2: 943-951.

110-Behravan, J., Hosseinzadeh, H., Rastgoo, A.,  Malekshah, O. M. and  Hessani, M. (2010).  Evaluation of the cytotoxic activity of crocin and safranal using potato disc and brine shrimp assays. Physiol Pharmacol., 13, 397-403.  

111- Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, Motamed-Shariaty V. Antiurolithiatic activity of Pinus eldarica medw: fruits aqueous extract in rats. Urol J. 2010 Fall;7(4):232-7.

112- Hariri AT, Moallem SA, Mahmoudi M, Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine. 2011 Apr 15;18(6):499-504.

113-Hosseinzadeh, H., Zarei, H. and Taghiabadi, E. (2011). Antinociceptive, anti-inflammatory and acute toxicity effects of Juglans regia L. leaves in mice. Iran. Red Crescent Med. J. 13, 27-33.

114-Hosseinzadeh, H., Behravan, J., Ramezani, M., Sarafraz, S. and Taghiabadi, E. (2011). Study of atitumor effect of methaolic and aqueous extracts of allium stivum l. (garlic) cloves using potato disc bioassay. Pharmacologyonline 1: 881-888

115-Hosseinzadeh, H., Jafarzadeh, S. and  Lari, P. (2011). Effects of aqueous and ethanolic leaf extracts of Mentha longifolia on morphine dependence in mice. Pharmacologyonline 1: 904-909

116-Imenshahidi, M., Zafari, H. and Hosseinzadeh, H. (2011). Effects of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Pharmacologyonline 1: 1007-1013

117-Hariri, A.T., Moallem, S.A., Mahmoudi, M., Memar, B., Hosseinzadeh, H.  (2011).  The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine. 18:499-504.

118-Hosseinzadeh H, Behravan E, M Soleimani M. (2011). Antinociceptive and anti-inflammatory effects of pistacia vera leafextract in mice. Iran J Pharm Res.10:821-8.

119-Mohajeri SA, Hosseinzadeh H, Salami S, Motamedshariaty V, Seifi M, Hadizadeh  F. 2011. Synthesis of novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] dihydropyridines and studying their effects on rat blood pressure. Iran J Basic Med Sci. 14:451-7.

120-Ramezani, M., Hosseinzadeh, H., Moradi, M. and Taghiabadi, E. (2011). Phototoxicity activity of Psoralea drupacea L. using Atremia salina bioassay System. Avicenna J Phytomed 1, 24-28.

121-Hosseinzadeh H, Khoshdel M, Ghorbani M. (2011). Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. aerial parts in mice. J Acupunct Meridian Stud.4:242-7.

122-Hosseinzadeh, H., Imenshahidi, M. and Arasteh, A. (2011). Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Avicenna J Phytomed. 2, 24-30.

123-Sahebari, M., Mahmoudi, Z., Zamani Taghizadeh S.R., Haghmorad, D., Mahmoudi, M.B., Hosseinzadeh, H., Tabasi, N., Mahmoudi, M. (2011) Inhibitory effect of aqueous extract of saffron (Crocus sativus L.) on adjuvant-induced arthritis in wistar rat. Pharmacologyonline 3: 802-808.

124-Hosseinzadeh, H., Sadeghnia, H. R., Ghaeni, F. A., Motamedshariaty, V. S. and Mohajeri, S. A. (2012). Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phythother. Res. 26:381-6.

125-Hajhashemi V, Hosseinzadeh H, Amin B. (2012). Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats Acta Neuropsych. 25, 27-32.

126-Amin, B. and Hosseinzadeh, H. (2012). Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 83:888-95

127-Amin, B., Hajhashemi, V., Hosseinzadeh, H., Abnous, Kh. (2012). Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat. Neuroscience. 224, 15-25.

128-Doosti F, Dashti S, Tabatabai SM, Hosseinzadeh H (2013). Traditional Chinese and Indian medicine in the treatment of opioid-dependence: a review. Avicenna J Phytomed 3: 205-215.

129-Hajhashemi V, Hosseinzadeh H, Amin B (2013). Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats. Acta Neuropsychiatrica 25: 27-32.

130-Hosseinzadeh H, Nassiri-Asl M (2013). Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res 27: 475-483.

131-Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E (2013). Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats. J Acupunct Meridian Stud 6: 18-23.

132-Hosseinzadeh H, Ramezani M, Shafaei H, Tahiabadi E (2013). Anticonvulsant effect of Berberis integerrima L. root extracts in mice. J Acupunct Meridian Stud 6: 12-17.

133-Hosseinzadeh H, Shakib SS, Sameni AK, Taghiabadi E (2013). Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iran J Pharmac Res12: 93-99.

134-Hosseinzadeh H, Mehri S, Abolhassani MM, Ramezani M, Sahebkar A, Abnous K (2013). Affinity-based target deconvolution of safranal. Daru 21: 25.

135-Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H (2013). The Effect of Chronic Administration of Saffron (Crocus sativus) Stigma Aqueous Extract on Systolic Blood Pressure in Rats. Jundishapur J Nat Pharm Prod 8: 175-179.

136-Marzieh R, Hosseinzadeh H, Mohsen I, Parisa L, Bibi Marjan R, Khalil A (2013). Effect of exposure to diazinon on adult rat's brain. Toxicol Ind Health.

137-Mehdizadeh R, Parizadeh MR, Khooei AR, Mehri S, Hosseinzadeh H (2013). Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. Iran J Basic Med Sci 16: 56-63.

138-Mohamadpour AH Ayati Z, Parizadeh MR, Rajbai O, Hosseinzadeh H (2013). Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers. Iran J Basic Med Sci 16: 39-46.

139-Mohammadpour AH, Ramezani M, Tavakoli Anaraki N, Malaekeh-Nikouei B, Amel Farzad S, Hosseinzadeh H (2013). Development and Validation of HPLC Method for Determination of Crocetin, a constituent of Saffron, in Human Serum Samples. Iran J Basic Med Sci 16: 47-55.

140-Moshiri M, Vahabzadeh M, Etemad L, Hosseinzadeh H (2013). Failure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats. Iran J Pharm Res 12: 897-902.

141-Rashedinia M, Lari P, Abnous K, Hosseinzadeh H (2013). Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity. Toxicol Appl Pharmacol 272: 199-207.

142-Rastgoo M, Hosseinzadeh H, Alavizadeh H, Abbasi A, Ayati Z, Jaafari MR (2013). Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma. Planta Med 79: 447-451.

143-Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M (2013). Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci 16: 64-72.

144-Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K (2013). Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact 203: 547-555.

145-Rezaee R, Hosseinzadeh H (2013). Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci 16: 12-26.

146-Tashakori-Sabzevar F, Hosseinzadeh H, Motamedshariaty VS, Movassaghi AR, Mohajeri SA (2013). Crocetin attenuates spatial learning dysfunction and hippocampal injury in a model of vascular dementia. Curr Neurovasc Res 10: 325-334.

147-Vahabzadeh M, Moshiri M, Mohammadpour AH, Hosseinzadeh H (2013). Promising effects of intravenous lipid emulsion as an antidote in acute tramadol poisoning. Reg Anesth Pain Med 38: 425-430.

148-Alavizadeh SH, Hosseinzadeh H (2014). Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol 64: 65-80.

149-Alipour G, Dashti S, Hosseinzadeh H (2014). Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytother Res 28: 1125-1136.

150-Amin B, Taheri MMH, Hosseinzadeh H (2014). Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats. Planta Med 80: 1269-1277.

151-Amin B, Abnous K, Motamedshariaty V, Hosseinzadeh H (2014). Attenuation of oxidative stress, inflammation and apoptosis by ethanolic and aqueous extracts of Crocus sativus L. stigma after chronic constriction injury of rats. An Acad Bras Cienc 86:1821-32

152-Amin B, Hajhashemi V, Abnous K, Hosseinzadeh H (2014). Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain. Biomed Res Int 2014: 937568.

153-Ayatollahi H, Javan AO, Khajedaluee M, Shahroodian M, Hosseinzadeh H (2014). Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers. Phytother Res 28: 539-543.

154-Behravan E, Razavi BM, Hosseinzadeh H (2014). Review of plants and their constituents in the therapy of cerebral ischemia. Phytother Res 28: 1265-1274.

155-Golmohammadzadeh S, Imani F, Hosseinzadeh H, Jaafari MR. Preparation, characterization and evaluation of sun protective and moisturizing effects of nanoliposomes containing safranal. Iran J Basic Med Sci. 2011 Nov;14(6):521-33.

156-Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Moh ajeri SA. (2012). Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res. 26:381-6.

157- Hosseinzadeh H, Zarei H, Taghiabadi E. (2012). Antinociceptive, anti-inflammatory and acute toxicity effects of Juglans regia L. Leaves in mice. Iran Red Crescent Med  J. 13:27-33.

158- Hosseinzadeh H, Shahandeh S, Shahsavand S. Anxiolytic and Hypnotic Effects of Aqueous and Ethanolic Extracts of Aerial Parts of Echium italicum L. in Mice. Jundishapur J Nat Pharm Prod. 2012 Spring;7(2):71-9.

159- Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012 Mar;32(2):227-35.

160- Hosseinzadeh H, Taiari S, Nassiri-Asl M. Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):503-8.

161- Hosseinzadeh H, Sajadi Tabassi SA, Milani Moghadam N, Rashedinia M, Mehri S.  Antioxidant Activity of Pistacia vera Fruits, Leaves and Gum Extracts. Iran J Pharm Res. 2012 Summer;11(3):879-87

162- Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM. Effect of linalool on morphine tolerance and dependence in mice. Phytother Res. 2012  Sep;26(9):1399-404.

163-  Hosseinzadeh H, Moallem SA, Moshiri M, Sarnavazi MS, Etemad L. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice. Arzneimittelforschung. 2012 Jul;62(7):324-9.

164-  Bazzaz BS, Lavaei S, Hosseinzadeh H. Interaction of methylxanthines and gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa: role of phosphodiesterase inhibition. Acta Microbiol Immunol Hung. 2012 Mar;59(1):13-20.

165-Forouzanfar F, Fazly Bazzaz BS, Hosseinzadeh H (2014). Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial effects. Iranian Journal of Basic Medical Sciences 17: 929-938.

166-Ghaeni FA, Amin B, Hariri AT, Meybodi NT, Hosseinzadeh H (2014). Antilithiatic effects of crocin on ethylene glycol-induced lithiasis in rats. Urolithiasis 42: 549-558.

167-Ghazanfari S, Imenshahidi M, Etemad L, Moshiri M, Hosseinzadeh H (2014). Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice. Drug Res (Stuttg) 64: 113-117.
168-Havakhah S, Sadeghnia HR, Hajzadeh MAR, Roshan NM, Shafiee S, Hosseinzadeh H, et al. (2014). Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage. Iran J Basic Med Sci 17: 986-992.

169-Hosseinzadeh H (2014). Saffron: a herbal medicine of third millennium. Jundishapur J Nat Pharm Prod 9: 1-2.

170- Hosseinzadeh H, Nassiri-Asl M (2014). Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid. J Endocrinol Invest 37: 783-788.

171- Hosseinzadeh H, Tafaghodi M, Abedzadeh S, Taghiabadi E (2014). Effect of aqueous and ethanolic extracts of Pimpinella anisum L. seeds on milk production in rats. J Acupunct Meridian Stud 7: 211-216.

172-Hosseinzadeh H, Mehri S, Heshmati A, Ramezani M, Sahebkar A, Abnous K (2014). Proteomic screening of molecular targets of crocin. Daru 22: 5.

173-Imenshahidi M, Qaredashi R, Hashemzaei M, Hosseinzadeh H (2014). Inhibitory effect of Berberis vulgaris aqueous extract on acquisition and reinstatement effects of morphine in conditioned place preferences (CPP) in Mice. Jundishapur J Nat Pharm Prod 9: e16145.

174-Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H (2014). Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iran J Basic Med Sci 17: 9-13.
175-Lari P, Rashedinia M, Abnous K, Hosseinzadeh H (2014). Alteration of protein profile in rat liver of animals exposed to subacute diazinon: a proteomic approach. Electrophoresis 35: 1419-1427.

176-Lari P, Rashedinia M, Abnous K, Hosseinzadeh H (2014). Crocin improves lipid dysregulation in subacute diazinon exposure through ERK1/2 pathway in rat liver. Drug Res (Stuttg) 64: 301-305.

177-Mehri S, Meshki MA, Hosseinzadeh H (2014). Linalool as a neuroprotective agent against acrylamide-induced neurotoxicity in Wistar rats. Drug Chem Toxicol: 1-5.

178-Mehri S, Veis Karami H, Vahdati Hassani F, Hosseinzadeh H (2014). Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments. Iranian Biomedical Journal 18: 101-106.

179-Mehri S, Shahi M, Razavi BM, Hassani FV, Hosseinzadeh H (2014). Neuroprotective effect of thymoquinone in acrylamideinduced neurotoxicity in wistar rats Iran J Basic Med Sci 17: 1007-1011.

180-Moallem SA, Hariri AT, Mahmoudi M, Hosseinzadeh H (2014). Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. Toxicol Ind Health 30: 141-146.

181-Mollazadeh H, Hosseinzadeh H (2014). The protective effect of Nigella sativa against liver injury: a review. Iran J Basic Med Sci 17: 958-966.

182-Moshiri M, Vahabzadeh M, Mohammadpour AH, Hosseinzadeh H (2014). Evaluation of intravenous lipid emulsion on haloperidol-induced hypotension in rabbits. Toxicol Ind Health. Epub ahead of print.

183-Moshiri M, Mohammadpour AH, Vahabzadeh M, Etemad L, Memar B, Hosseinzadeh H (2014). Evaluating the effects and safety of intravenous lipid emulsion on haloperidol-induced neurotoxicity in rabbit. Biomed Res Int 2014: 949262.

184-Motamedshariaty VS, Amel Farzad S, Nassiri-Asl M, Hosseinzadeh H (2014). Effects of rutin on acrylamide-induced neurotoxicity. Daru 22: 27.

185-Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini SM, Hosseinzadeh H (2014). Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci 17: 1020-1031.

186-Razavi BM, Hosseinzadeh H (2014). A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. J Endocrinol Invest. 37:1031-40

187-Razavi BM, Hosseinzadeh H, Abnous K, Imenshahidi M (2014). Protective effect of crocin on diazinon induced vascular toxicity in subchronic exposure in rat aorta ex-vivo. Drug and Chemical Toxicology 37: 378-383.

188-Razavi BM, Hosseinzadeh H, Imenshahidi M, Malekian M, Ramezani M, Abnous K (2014). Evaluation of Protein Ubiquitylation in Heart Tissue of Rats Exposed to Diazinon (an Organophosphate Insecticide) and Crocin (an Active Saffron Ingredient): Role of HIF-1alpha. Drug Res (Stuttg).

189-Tabatabai SM, Dashti S, Doosti F, Hosseinzadeh H (2014). Phytotherapy of opioid dependence and withdrawal syndrome: a review. Phytother Res 28: 811-830.

190-Vahdati Hassani F, Naseri V, Razavi BM, Mehri S, Abnous K, Hosseinzadeh H (2014). Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru 22: 16.

191-Ziaee T, Razavi BM, Hosseinzadeh H (2014). Saffron reduced toxic effects of its constituent, safranal, in acute and subacute toxicities in rats. Jundishapur J Nat Pharm Prod 9: 3-8.

192-Amin B, Hosseinzadeh H (2015). Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects. Planta Med.

193-Amin B, Hajhashemi V, Hosseinzadeh H (2015). Minocycline potentiates the anti-hyperalgesic effect of ceftriaxone in CCI-induced neuropathic pain in rats. Res Pharmac Sci 10: 35-43.

194-Amin B, Malekzadeh M, Heidari MR, Hosseinzadeh H (2015). Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice. Iran J Basic Med Sci 18: 449-458.

195-Amin B, Moghri Feriz H, Timcheh Hariri A, Tayyebi Meybodi N, Hosseinzadeh H (2015). Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats. EXCLI Journal 14: 411-422.

196-Ardebili Dorri S, Hosseinzadeh H, Abnous K, Vahdati Hasani F, Yazdian Robati R, Razavi BM (2015). Involvement of brain‐derived neurotrophic factor (BDNF) on malathion induced depressive‐like behavior in subacute exposure and protective effects of crocin. Iran J Basic Med Sci. 18: 958-966.

197-Esmaeelpanah E, Rahmatkhah A, Poormahmood N, Razavi BM, Hasani FV, Hosseinzadeh H (2015). Protective effect of green tea aqueous extract on acrylamide induced neurotoxicity. Jundishapur J Nat Pharm Prod 10: 1-5.

198-Etemad L, Zafari R, Vahdati-Mashhadian N, Adel Moallem S, Shirvan ZO, Hosseinzadeh H (2015). Acute, sub-acute and cell toxicity of Verbascoside. Res J Med Plant 9: 354-360.

199-Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H (2015). Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. Drug Res (Stuttg) 65: 7.

200-Hosseini A, Hosseinzadeh H (2015). A review on the effects of Allium sativum (Garlic) in metabolic syndrome. J Endocrinol Invest. 38:1147-57

201-Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H (2015). The effect of chronic administration of safranal on systolic blood pressure in rats. Iran J Pharm Res 14: 585-590.

202-Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H (2015). Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health 31: 367-376.

203-Mehri S, Abnous K, Khooei A, Mousavi SH, Shariaty VM, Hosseinzadeh H (2015). Crocin reduced acrylamide-induced neurotoxicity in wistar rat through inhibition of oxidative stress. Iran J Basic Med Sci. 18: 902-908.

204-Moshiri M, Vahabzadeh M, Hosseinzadeh H (2015). Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review. Drug Res (Stuttg) 65: 287-295.

205-Rashedinia M, Lari P, Abnous K, Hosseinzadeh H (2015). Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain. Acta Neurobiol Exp (Wars) 75: 208-219.

206-Razavi BM, Hosseinzadeh H (2015). Saffron as an antidote or a protective agent against natural or chemical toxicities. Daru 23: 31.

207-Zamani Taghizadeh Rabe S, Sahebari M, Mahmoudi Z, Hosseinzadeh H, Haghmorad D, Tabasi N, et al. (2015). Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis. Food and Agricultural Immunology 26: 170-180.

208-Vahdati Hassani F, Hashemzaei M, Akbari E, Imenshahidi M, Hosseinzadeh H. Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice. Avicenna J Phytomed, 2015. Epub ahead of print

209-Hosseinzadeh H, Parvardeh S, Masoudi A, Moghimi M, Mahboobifard F. Attenuation of morphine tolerance and dependence by thymoquinone in mice. Avicenna J Phytomed, 2015. Epub ahead of print.

210-Zolfagharian F, Razavi BM, Hosseinzadeh H. Anticonvulsant effect of Satureja hortensis L. aerial parts extracts in mice. Avicenna J Phytomed, 2015. Epub ahead of print.

211-Akaberi, M. and Hosseinzadeh, H. Grapes (Vitis vinifera) a candida for the treatment of metabolic syndrome. Phytotherapy Res. 2015. Epub ahead of print.

212-Hosseinzadeh H, Nassiri-Asl M. Pharmacological effects of glycyrrhiza spp. and its bioactive constituents: update and review. Phytother Res. 2015 29: 1868–1886.

213-Pourtaji A, Robati RY, Lari P, Hosseinzadeh H, Ramezani M, Abnous K.Proteomics screening of adenosine triphosphate-interacting proteins in the liver of diazinon-treated rats. Hum Exp Toxicol. 2015 Dec 31. pii: 0960327115619771.

214-Dorri SA, Hosseinzadeh H, Abnous K, Hasani FV, Robati RY, Razavi BM. Involvement of brain-derived neurotrophic factor (BDNF) on malathion induced depressive-like behavior in subacute exposure and protective effects of crocin.Iran J Basic Med Sci. 2015 Oct;18(10):958-66.

215-Moallem SA, Afshar M, Etemad L, Razavi BM, Hosseinzadeh H (2016). Evaluation of teratogenic effects of crocin and safranal, active ingredients of saffron, in mice. Toxicol Ind Health. 32:285-91

                                                                      Presentations

Hosseinzadeh, H. (2015). Pharmacological effects of black cumin (Nigellaa sativa) and its active constituents. 7-11 Sep. 22nd Iranian Congress of Physiology & Pharmacology. Kashan, Iran

Hosseinzadeh, H. and Razavi, BM. (2015). The effects of Crocus sativus L. and its active constituents in metabolic syndrome.International Congress of Quality, Safety and Rational Use of Drug. 4-6 Nov.

Hosseinzadeh, H. (2015). Herbal-Drug Interaction.The First International Congress on Complementary and Alternative Medicine. 7-9 Oct. Mashhad

Hosseinzadeh, H. (2014). Effect of thymoquinone and Nigella sativa seeds oil on ethanol toxicity in rats. First International Congress of. Alcohol Abuse.Mashhad.

Honors & Awards

First Rank, Pharmaceutical Research : 7th Razi Research Festival on Medical Sciences, 2001

MUMS Best Researcher Award, Mashhad Iran:2001, 2002, 2003, and 2004, 2011, 2012, 2013,2014,2015

Iranian Association of Pharmaceutical Scientists Award as a best academic researcher in Iran, 2004, Tabriz,

Second Rank, Pharmaceutical Research : 12th Razi Research Festival on Medical Sciences, 2006

First and Second Rank of Motahari Festival Award in Education, School of Pharmacy, MUMS, Mashhad, Iran, 2011 and 2012

Distinguished teacher in the 16th Ibn-Sina Festival, Tehran University of Medical Sciences, 2015

Listed among 1% top scientists of the World as reported by Essential Science Indicator of Thompson Reuter ISI. (In the field of pharmacology and toxicology: International rank (May 2016:741, National Rank:2)

Listed one paper among 1% top papers of the World as reported by Essential Science Indicator of Thompson Reuter ISI. [Asl, M.N. and Hosseinzadeh, H. (2008).  Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res.22:709-24.]

First Rank, Pharmaceutical Research : The 21th Razi Research Festival on Medical Sciences, 2015

Members                                                  hip Membership

                                                           Administrative Responsibilities

Head, Pharmacology and Toxicology Department, School of Pharmacy, Mashhad, Iran: 1995-2000

Dean, School of Pharmacy, Mashhad, Iran: 1997-2011

Head, Pharmaceutical Research,Center, Buali Research Institute, Mashhad, Iran: 1999-2002

MUMS Publication Committee. Mashhad, Iran